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Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis.
Acta Neurol Scand 2006; 113(1):40-5AN

Abstract

OBJECTIVES

We measured the volumes of the amygdala to test the hypothesis that the reduction of amygdalar volume may be associated with psychiatric symptoms in Alzheimer's disease.

MATERIALS AND METHODS

Twenty-seven patients underwent neuropsychological investigation including the assessment of general clinical severity by the Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI). All patients underwent magnetic resonance imaging (MRI) of the head, from which the volumes of the amygdalae were measured. The obtained values were compared with those of controls (n = 15).

RESULTS

Patients with Alzheimer's dementia showed significant reduction in MRI volumetric measurements compared with controls. We found a significant correlation of MMSE score and absolute amygdala volume (r = 0.62, P < 0.01). Neither the absolute nor relative volume of the amygdala showed any correlation with NPI scores.

CONCLUSIONS

The atrophy of the amygdala does not have a direct association with the existence of neuropsychiatric symptoms. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease.

Authors+Show Affiliations

First Medical School, Institute of Anatomy, Charles University, Prague, Czech Republic. dhori@email.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16367898

Citation

Horínek, D, et al. "Amygdalar Volume and Psychiatric Symptoms in Alzheimer's Disease: an MRI Analysis." Acta Neurologica Scandinavica, vol. 113, no. 1, 2006, pp. 40-5.
Horínek D, Petrovický P, Hort J, et al. Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. Acta Neurol Scand. 2006;113(1):40-5.
Horínek, D., Petrovický, P., Hort, J., Krásenský, J., Brabec, J., Bojar, M., ... Seidl, Z. (2006). Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. Acta Neurologica Scandinavica, 113(1), pp. 40-5.
Horínek D, et al. Amygdalar Volume and Psychiatric Symptoms in Alzheimer's Disease: an MRI Analysis. Acta Neurol Scand. 2006;113(1):40-5. PubMed PMID: 16367898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. AU - Horínek,D, AU - Petrovický,P, AU - Hort,J, AU - Krásenský,J, AU - Brabec,J, AU - Bojar,M, AU - Vanecková,M, AU - Seidl,Z, PY - 2005/12/22/pubmed PY - 2006/6/9/medline PY - 2005/12/22/entrez SP - 40 EP - 5 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 113 IS - 1 N2 - OBJECTIVES: We measured the volumes of the amygdala to test the hypothesis that the reduction of amygdalar volume may be associated with psychiatric symptoms in Alzheimer's disease. MATERIALS AND METHODS: Twenty-seven patients underwent neuropsychological investigation including the assessment of general clinical severity by the Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI). All patients underwent magnetic resonance imaging (MRI) of the head, from which the volumes of the amygdalae were measured. The obtained values were compared with those of controls (n = 15). RESULTS: Patients with Alzheimer's dementia showed significant reduction in MRI volumetric measurements compared with controls. We found a significant correlation of MMSE score and absolute amygdala volume (r = 0.62, P < 0.01). Neither the absolute nor relative volume of the amygdala showed any correlation with NPI scores. CONCLUSIONS: The atrophy of the amygdala does not have a direct association with the existence of neuropsychiatric symptoms. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/16367898/Amygdalar_volume_and_psychiatric_symptoms_in_Alzheimer's_disease:_an_MRI_analysis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-6314&amp;date=2006&amp;volume=113&amp;issue=1&amp;spage=40 DB - PRIME DP - Unbound Medicine ER -