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Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis.

Abstract

OBJECTIVES

We measured the volumes of the amygdala to test the hypothesis that the reduction of amygdalar volume may be associated with psychiatric symptoms in Alzheimer's disease.

MATERIALS AND METHODS

Twenty-seven patients underwent neuropsychological investigation including the assessment of general clinical severity by the Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI). All patients underwent magnetic resonance imaging (MRI) of the head, from which the volumes of the amygdalae were measured. The obtained values were compared with those of controls (n = 15).

RESULTS

Patients with Alzheimer's dementia showed significant reduction in MRI volumetric measurements compared with controls. We found a significant correlation of MMSE score and absolute amygdala volume (r = 0.62, P < 0.01). Neither the absolute nor relative volume of the amygdala showed any correlation with NPI scores.

CONCLUSIONS

The atrophy of the amygdala does not have a direct association with the existence of neuropsychiatric symptoms. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease.

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  • Authors+Show Affiliations

    ,

    First Medical School, Institute of Anatomy, Charles University, Prague, Czech Republic. dhori@email.cz

    , , , , , ,

    Source

    Acta neurologica Scandinavica 113:1 2006 Jan pg 40-5

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Amygdala
    Atrophy
    Cross-Sectional Studies
    Female
    Humans
    Magnetic Resonance Imaging
    Male
    Mental Disorders
    Mental Status Schedule
    Middle Aged
    Neuropsychological Tests
    Severity of Illness Index

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16367898

    Citation

    Horínek, D, et al. "Amygdalar Volume and Psychiatric Symptoms in Alzheimer's Disease: an MRI Analysis." Acta Neurologica Scandinavica, vol. 113, no. 1, 2006, pp. 40-5.
    Horínek D, Petrovický P, Hort J, et al. Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. Acta Neurol Scand. 2006;113(1):40-5.
    Horínek, D., Petrovický, P., Hort, J., Krásenský, J., Brabec, J., Bojar, M., ... Seidl, Z. (2006). Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. Acta Neurologica Scandinavica, 113(1), pp. 40-5.
    Horínek D, et al. Amygdalar Volume and Psychiatric Symptoms in Alzheimer's Disease: an MRI Analysis. Acta Neurol Scand. 2006;113(1):40-5. PubMed PMID: 16367898.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis. AU - Horínek,D, AU - Petrovický,P, AU - Hort,J, AU - Krásenský,J, AU - Brabec,J, AU - Bojar,M, AU - Vanecková,M, AU - Seidl,Z, PY - 2005/12/22/pubmed PY - 2006/6/9/medline PY - 2005/12/22/entrez SP - 40 EP - 5 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 113 IS - 1 N2 - OBJECTIVES: We measured the volumes of the amygdala to test the hypothesis that the reduction of amygdalar volume may be associated with psychiatric symptoms in Alzheimer's disease. MATERIALS AND METHODS: Twenty-seven patients underwent neuropsychological investigation including the assessment of general clinical severity by the Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI). All patients underwent magnetic resonance imaging (MRI) of the head, from which the volumes of the amygdalae were measured. The obtained values were compared with those of controls (n = 15). RESULTS: Patients with Alzheimer's dementia showed significant reduction in MRI volumetric measurements compared with controls. We found a significant correlation of MMSE score and absolute amygdala volume (r = 0.62, P < 0.01). Neither the absolute nor relative volume of the amygdala showed any correlation with NPI scores. CONCLUSIONS: The atrophy of the amygdala does not have a direct association with the existence of neuropsychiatric symptoms. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/16367898/Amygdalar_volume_and_psychiatric_symptoms_in_Alzheimer's_disease:_an_MRI_analysis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-6314&amp;date=2006&amp;volume=113&amp;issue=1&amp;spage=40 DB - PRIME DP - Unbound Medicine ER -