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Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression).
Biol Psychiatry. 2006 Apr 15; 59(8):696-701.BP

Abstract

BACKGROUND

Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression.

METHODS

We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment.

RESULTS

Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05).

CONCLUSIONS

In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, The Netherlands. b.c.appelhof@amc.iva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16368077

Citation

Appelhof, Bente C., et al. "Glucocorticoids and Relapse of Major Depression (dexamethasone/corticotropin-releasing Hormone Test in Relation to Relapse of Major Depression)." Biological Psychiatry, vol. 59, no. 8, 2006, pp. 696-701.
Appelhof BC, Huyser J, Verweij M, et al. Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biol Psychiatry. 2006;59(8):696-701.
Appelhof, B. C., Huyser, J., Verweij, M., Brouwer, J. P., van Dyck, R., Fliers, E., Hoogendijk, W. J., Tijssen, J. G., Wiersinga, W. M., & Schene, A. H. (2006). Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biological Psychiatry, 59(8), 696-701.
Appelhof BC, et al. Glucocorticoids and Relapse of Major Depression (dexamethasone/corticotropin-releasing Hormone Test in Relation to Relapse of Major Depression). Biol Psychiatry. 2006 Apr 15;59(8):696-701. PubMed PMID: 16368077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). AU - Appelhof,Bente C, AU - Huyser,Jochanan, AU - Verweij,Mijke, AU - Brouwer,Jantien P, AU - van Dyck,Richard, AU - Fliers,Eric, AU - Hoogendijk,Witte J G, AU - Tijssen,Jan G P, AU - Wiersinga,Wilmar M, AU - Schene,Aart H, Y1 - 2005/12/20/ PY - 2004/09/13/received PY - 2005/01/14/revised PY - 2005/09/08/accepted PY - 2005/12/22/pubmed PY - 2006/6/3/medline PY - 2005/12/22/entrez SP - 696 EP - 701 JF - Biological psychiatry JO - Biol Psychiatry VL - 59 IS - 8 N2 - BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16368077/Glucocorticoids_and_relapse_of_major_depression__dexamethasone/corticotropin_releasing_hormone_test_in_relation_to_relapse_of_major_depression__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)01204-7 DB - PRIME DP - Unbound Medicine ER -