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Diet and diabetic retinopathy: insights from the Diabetes Control and Complications Trial (DCCT).

Abstract

OBJECTIVE

We explore the influence of lifestyle on the progression of retinopathy.

DESIGN

Post hoc statistical analysis.

SUBJECTS/SETTING

One thousand forty-one patients with type 1 diabetes from 29 specialty clinics.

INTERVENTION

The Diabetes Control and Complications Trial (DCCT) lifestyle data (diet, exercise, and tobacco use) and retinopathy-related risk factors (mean arterial pressure, the low-density lipoprotein/high-density lipoprotein cholesterol ratio [LDL-C/HDL-C], serum triglycerides, glycosolated hemoglobin [HbA1c] levels, body mass index [BMI], and insulin utilization) were related to the rate of progression of retinopathy.

MAIN OUTCOME MEASURES

Correlation between lifestyle data with progression of retinopathy and retinopathy-related risk factors.

RESULTS

The percentage of calories as total fatty acids at baseline and overall positively correlated with prestudy and overall progression of retinopathy (r = .15, P < .0001 and r = .14, P < .0001, respectively). Average overall percentage of calories as dietary fiber inversely correlated with prestudy and overall progression of retinopathy (r = -.07, P = .0102 and r = -.10, P < .0002, respectively). The progression of retinopathy correlated with mean arterial pressure (prestudy r = .09, P = .0004 and overall r = .20, P < .0001), LDL-C/HDL-C (prestudy r = .13, P < .0001 and overall r = .15, P < .0001), serum triglycerides (prestudy r = .18, P < .0001 and overall r = .26, P < .0001), HbA1c (prestudy r = .10, P < .0001 and overall r = .45, P < .0001), BMI (prestudy r = .08, P <.0034 and overall r = .05, P = .08), insulin utilization (prestudy r = .19, P < .0001 and overall r = .14, P < .0001), tobacco use (prestudy r = .08, P < .0231 and overall r = .09, P < .0011), and the intensive vs conventional therapy study group (on-study r = -.27, P < .0001).

CONCLUSION

Tobacco use and diet, particularly the consumption of fatty acids and dietary fiber, are significantly associated with the rate of progression of diabetic retinopathy and retinopathy-related risk factors.

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  • Authors+Show Affiliations

    ,

    Department of Public Health Sciences & Epidemiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, USA.

    Source

    MeSH

    Adolescent
    Adult
    Diabetic Retinopathy
    Disease Progression
    Female
    Humans
    Life Style
    Male
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16369308

    Citation

    Cundiff, David K., and Claudio R. Nigg. "Diet and Diabetic Retinopathy: Insights From the Diabetes Control and Complications Trial (DCCT)." MedGenMed : Medscape General Medicine, vol. 7, no. 1, 2005, p. 3.
    Cundiff DK, Nigg CR. Diet and diabetic retinopathy: insights from the Diabetes Control and Complications Trial (DCCT). MedGenMed. 2005;7(1):3.
    Cundiff, D. K., & Nigg, C. R. (2005). Diet and diabetic retinopathy: insights from the Diabetes Control and Complications Trial (DCCT). MedGenMed : Medscape General Medicine, 7(1), p. 3.
    Cundiff DK, Nigg CR. Diet and Diabetic Retinopathy: Insights From the Diabetes Control and Complications Trial (DCCT). MedGenMed. 2005 Jan 6;7(1):3. PubMed PMID: 16369308.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet and diabetic retinopathy: insights from the Diabetes Control and Complications Trial (DCCT). AU - Cundiff,David K, AU - Nigg,Claudio R, Y1 - 2005/01/06/ PY - 2005/12/22/pubmed PY - 2006/6/9/medline PY - 2005/12/22/entrez SP - 3 EP - 3 JF - MedGenMed : Medscape general medicine JO - MedGenMed VL - 7 IS - 1 N2 - OBJECTIVE: We explore the influence of lifestyle on the progression of retinopathy. DESIGN: Post hoc statistical analysis. SUBJECTS/SETTING: One thousand forty-one patients with type 1 diabetes from 29 specialty clinics. INTERVENTION: The Diabetes Control and Complications Trial (DCCT) lifestyle data (diet, exercise, and tobacco use) and retinopathy-related risk factors (mean arterial pressure, the low-density lipoprotein/high-density lipoprotein cholesterol ratio [LDL-C/HDL-C], serum triglycerides, glycosolated hemoglobin [HbA1c] levels, body mass index [BMI], and insulin utilization) were related to the rate of progression of retinopathy. MAIN OUTCOME MEASURES: Correlation between lifestyle data with progression of retinopathy and retinopathy-related risk factors. RESULTS: The percentage of calories as total fatty acids at baseline and overall positively correlated with prestudy and overall progression of retinopathy (r = .15, P < .0001 and r = .14, P < .0001, respectively). Average overall percentage of calories as dietary fiber inversely correlated with prestudy and overall progression of retinopathy (r = -.07, P = .0102 and r = -.10, P < .0002, respectively). The progression of retinopathy correlated with mean arterial pressure (prestudy r = .09, P = .0004 and overall r = .20, P < .0001), LDL-C/HDL-C (prestudy r = .13, P < .0001 and overall r = .15, P < .0001), serum triglycerides (prestudy r = .18, P < .0001 and overall r = .26, P < .0001), HbA1c (prestudy r = .10, P < .0001 and overall r = .45, P < .0001), BMI (prestudy r = .08, P <.0034 and overall r = .05, P = .08), insulin utilization (prestudy r = .19, P < .0001 and overall r = .14, P < .0001), tobacco use (prestudy r = .08, P < .0231 and overall r = .09, P < .0011), and the intensive vs conventional therapy study group (on-study r = -.27, P < .0001). CONCLUSION: Tobacco use and diet, particularly the consumption of fatty acids and dietary fiber, are significantly associated with the rate of progression of diabetic retinopathy and retinopathy-related risk factors. SN - 1531-0132 UR - https://www.unboundmedicine.com/medline/citation/16369308/full_citation L2 - http://www.medscape.com/viewarticle/496168 DB - PRIME DP - Unbound Medicine ER -