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Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease.
Med Sci Monit. 2006 Jan; 12(1):CR17-20.MS

Abstract

BACKGROUND

Adiponectin, an adipocyte-derived hormone is implicated in insulin resistance and atherosclerosis. The aim of our study is to compare the levels of adiponectin in subjects with prediabetes and diabetes with subjects with normal glucose.

MATERIAL/METHODS

In a cross sectional study, we measured adiponectin and insulin in addition to fasting lipid panel and glucose in 28 subjects with prediabetes, 28 subjects with normal fasting glucose and 33 subjects with type 2 diabetes.

RESULTS

Adiponectin levels negatively correlate with insulin resistance index (r = -32.7). There is a significant difference in the levels of adiponectin between subjects with prediabetes and normal fasting glucose. There is a significant difference in adiponectin levels in subjects with prediabetes with Coronary artery disease (CAD) compared to those without CAD (10.24+/-1.02 vs. 7.02+/-0.92 with p<0.01). There is a significant difference in adiponectin levels in subjects with CAD compared to those without coronary artery disease (9.94+/-1.02 vs. 5.02+/-0.82 with p<0.01).

CONCLUSIONS

We conclude that decreased plasma adiponectin and insulin resistance coexist in subjects with prediabetes, diabetes and atherosclerosis. Adiponectin concentration is an independent correlate of insulin resistance and atherosclerosis.

Authors+Show Affiliations

Yaturu S
Department of Endocrinology, Overton Brooks VA Medical Center, Louisiana State University Health Sciences Center, Shreveport, LA 71101-4295, U.S.A. Subhashini.Yaturu@med.va.gov
Bridges JF
No affiliation info available
Subba Reddy DR
No affiliation info available

MeSH

AdiponectinAgedBlood GlucoseCoronary Artery DiseaseCross-Sectional StudiesDiabetes Mellitus, Type 2HumansInsulin ResistanceMiddle AgedPrediabetic State

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16369465

Citation

Yaturu, Subhashini, et al. "Decreased Levels of Plasma Adiponectin in Prediabetes, Type 2 Diabetes and Coronary Artery Disease." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 12, no. 1, 2006, pp. CR17-20.
Yaturu S, Bridges JF, Subba Reddy DR. Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease. Med Sci Monit. 2006;12(1):CR17-20.
Yaturu, S., Bridges, J. F., & Subba Reddy, D. R. (2006). Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 12(1), CR17-20.
Yaturu S, Bridges JF, Subba Reddy DR. Decreased Levels of Plasma Adiponectin in Prediabetes, Type 2 Diabetes and Coronary Artery Disease. Med Sci Monit. 2006;12(1):CR17-20. PubMed PMID: 16369465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased levels of plasma adiponectin in prediabetes, Type 2 diabetes and coronary artery disease. AU - Yaturu,Subhashini, AU - Bridges,Juanita F, AU - Subba Reddy,Dhani Reddy Rama, Y1 - 2005/12/19/ PY - 2005/08/03/received PY - 2005/08/18/accepted PY - 2005/12/22/pubmed PY - 2006/3/28/medline PY - 2005/12/22/entrez SP - CR17 EP - 20 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 12 IS - 1 N2 - BACKGROUND: Adiponectin, an adipocyte-derived hormone is implicated in insulin resistance and atherosclerosis. The aim of our study is to compare the levels of adiponectin in subjects with prediabetes and diabetes with subjects with normal glucose. MATERIAL/METHODS: In a cross sectional study, we measured adiponectin and insulin in addition to fasting lipid panel and glucose in 28 subjects with prediabetes, 28 subjects with normal fasting glucose and 33 subjects with type 2 diabetes. RESULTS: Adiponectin levels negatively correlate with insulin resistance index (r = -32.7). There is a significant difference in the levels of adiponectin between subjects with prediabetes and normal fasting glucose. There is a significant difference in adiponectin levels in subjects with prediabetes with Coronary artery disease (CAD) compared to those without CAD (10.24+/-1.02 vs. 7.02+/-0.92 with p<0.01). There is a significant difference in adiponectin levels in subjects with CAD compared to those without coronary artery disease (9.94+/-1.02 vs. 5.02+/-0.82 with p<0.01). CONCLUSIONS: We conclude that decreased plasma adiponectin and insulin resistance coexist in subjects with prediabetes, diabetes and atherosclerosis. Adiponectin concentration is an independent correlate of insulin resistance and atherosclerosis. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/16369465/Decreased_levels_of_plasma_adiponectin_in_prediabetes_Type_2_diabetes_and_coronary_artery_disease_ DB - PRIME DP - Unbound Medicine ER -