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Effects of peritoneal lavage with scolicidal agents on survival and adhesion formation in rats.
World J Surg 2006; 30(1):127-33WJ

Abstract

Intraoperative irrigation of the peritoneal cavity with scolicidal agents is frequently recommended when dealing with traumatic or spontaneous rupture of hydatid cysts. The present experimental study was designed to examine the influence of various scolicidal agents on adhesion formation and survival. A total of 149 rats were randomly allocated to nine groups. Peritoneal lavage through a median laparotomy was performed with the following scolicidal agents. Group 1 (0.9% saline: controls), group 2 (20% hypertonic saline), group 3 (0.04% chlorhexidine gluconate), group 4 (3% hydrogen peroxide), group 5 (0.5% silver nitrate), group 6 (1% polyvinylpyrrolidone-iodine, or PVP-I), group 7 (5% PVP-I), group 8 (0.5% cetrimide/0.05% chlorhexidine), and group 9 (10% PVP-I). The surviving animals were sacrificed on postoperative day 15. Adhesion formation was macroscopically graded by the Nair criteria. The severity of adhesion formation was evaluated microscopically using the fibrosing scoring criteria and the strain test. Group 9 (10% PVP-I) was excluded from the adhesion evaluation because all of the rats died in this group. The mortality rate was significantly higher in groups 5 and 7 than in groups 1, 2, 3, 4, 6, and 8. Adhesion scores were significantly lower in groups 1, 2, 3, and 4 than in groups 5, 6, 7, and 8. The lowest adhesion score was found in group 3 and the highest in the group 7. These results indicate that 0.04% chlorhexidine gluconate, the most potent scolicidal agent in vitro and in vivo, was associated with the lowest adhesion formation and mortality among various scolicidal agents in this experimental study.

Authors+Show Affiliations

Department of General Surgery, Cumhuriyet University, School of Medicine, Sivas, 58140, Turkey. otopcu@cumhuriyet.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16369703

Citation

Topcu, Omer, et al. "Effects of Peritoneal Lavage With Scolicidal Agents On Survival and Adhesion Formation in Rats." World Journal of Surgery, vol. 30, no. 1, 2006, pp. 127-33.
Topcu O, Kuzu I, Karayalcin K. Effects of peritoneal lavage with scolicidal agents on survival and adhesion formation in rats. World J Surg. 2006;30(1):127-33.
Topcu, O., Kuzu, I., & Karayalcin, K. (2006). Effects of peritoneal lavage with scolicidal agents on survival and adhesion formation in rats. World Journal of Surgery, 30(1), pp. 127-33.
Topcu O, Kuzu I, Karayalcin K. Effects of Peritoneal Lavage With Scolicidal Agents On Survival and Adhesion Formation in Rats. World J Surg. 2006;30(1):127-33. PubMed PMID: 16369703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of peritoneal lavage with scolicidal agents on survival and adhesion formation in rats. AU - Topcu,Omer, AU - Kuzu,Isinsu, AU - Karayalcin,Kaan, PY - 2005/12/22/pubmed PY - 2006/3/11/medline PY - 2005/12/22/entrez SP - 127 EP - 33 JF - World journal of surgery JO - World J Surg VL - 30 IS - 1 N2 - Intraoperative irrigation of the peritoneal cavity with scolicidal agents is frequently recommended when dealing with traumatic or spontaneous rupture of hydatid cysts. The present experimental study was designed to examine the influence of various scolicidal agents on adhesion formation and survival. A total of 149 rats were randomly allocated to nine groups. Peritoneal lavage through a median laparotomy was performed with the following scolicidal agents. Group 1 (0.9% saline: controls), group 2 (20% hypertonic saline), group 3 (0.04% chlorhexidine gluconate), group 4 (3% hydrogen peroxide), group 5 (0.5% silver nitrate), group 6 (1% polyvinylpyrrolidone-iodine, or PVP-I), group 7 (5% PVP-I), group 8 (0.5% cetrimide/0.05% chlorhexidine), and group 9 (10% PVP-I). The surviving animals were sacrificed on postoperative day 15. Adhesion formation was macroscopically graded by the Nair criteria. The severity of adhesion formation was evaluated microscopically using the fibrosing scoring criteria and the strain test. Group 9 (10% PVP-I) was excluded from the adhesion evaluation because all of the rats died in this group. The mortality rate was significantly higher in groups 5 and 7 than in groups 1, 2, 3, 4, 6, and 8. Adhesion scores were significantly lower in groups 1, 2, 3, and 4 than in groups 5, 6, 7, and 8. The lowest adhesion score was found in group 3 and the highest in the group 7. These results indicate that 0.04% chlorhexidine gluconate, the most potent scolicidal agent in vitro and in vivo, was associated with the lowest adhesion formation and mortality among various scolicidal agents in this experimental study. SN - 0364-2313 UR - https://www.unboundmedicine.com/medline/citation/16369703/Effects_of_peritoneal_lavage_with_scolicidal_agents_on_survival_and_adhesion_formation_in_rats_ L2 - https://dx.doi.org/10.1007/s00268-005-7960-4 DB - PRIME DP - Unbound Medicine ER -