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Short-term effects of hormone therapy on serum C-reactive protein levels in postmenopausal women.
Arch Gynecol Obstet. 2006 Apr; 274(1):9-12.AG

Abstract

OBJECTIVES

The aim of this study was to investigate the effects of tibolone and conjugated equine estrogens (CEEs) plus medroxyprogesterone acetate (MPA) (CEE + MPA) on levels of serum C-reactive protein (CRP), an independent risk factor for cardiovascular disorders, in postmenopausal women.

STUDY DESIGN

In this prospective randomized study, we randomly assigned 58 healthy postmenopausal women to CEE (0.625 mg/day) plus MPA (2.5 mg/day) (CEE + MPA) or tibolone (2.5 mg/day). The serum levels of CRP at 3 months after starting treatment were compared with baseline values for both therapies.

RESULTS

After 3 months of treatment the median CRP levels increased by 29% in the CEE + MPA group and by 5% in the tibolone group. But, these changes did not have statistical significance (P=0.15, P=0.06, respectively).

CONCLUSIONS

Our findings show that neither tibolone nor CEE + MPA caused significant changes in serum CRP levels in postmenopausal women. The potential impact of hormone therapy on serum CRP levels should be investigated in ongoing clinical trials.

Authors+Show Affiliations

Prof. Dr. M. Turan Cetin Women HeaIth and IVF Center, 100.yil Mah.132.Sk.No:1 CarrefourSA yani, 01104, Adana, Turkey. hakankiran01@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16369811

Citation

Kiran, Hakan, and Gurkan Kiran. "Short-term Effects of Hormone Therapy On Serum C-reactive Protein Levels in Postmenopausal Women." Archives of Gynecology and Obstetrics, vol. 274, no. 1, 2006, pp. 9-12.
Kiran H, Kiran G. Short-term effects of hormone therapy on serum C-reactive protein levels in postmenopausal women. Arch Gynecol Obstet. 2006;274(1):9-12.
Kiran, H., & Kiran, G. (2006). Short-term effects of hormone therapy on serum C-reactive protein levels in postmenopausal women. Archives of Gynecology and Obstetrics, 274(1), 9-12.
Kiran H, Kiran G. Short-term Effects of Hormone Therapy On Serum C-reactive Protein Levels in Postmenopausal Women. Arch Gynecol Obstet. 2006;274(1):9-12. PubMed PMID: 16369811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of hormone therapy on serum C-reactive protein levels in postmenopausal women. AU - Kiran,Hakan, AU - Kiran,Gurkan, Y1 - 2005/12/21/ PY - 2005/02/28/received PY - 2005/11/16/accepted PY - 2005/12/22/pubmed PY - 2008/2/20/medline PY - 2005/12/22/entrez SP - 9 EP - 12 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 274 IS - 1 N2 - OBJECTIVES: The aim of this study was to investigate the effects of tibolone and conjugated equine estrogens (CEEs) plus medroxyprogesterone acetate (MPA) (CEE + MPA) on levels of serum C-reactive protein (CRP), an independent risk factor for cardiovascular disorders, in postmenopausal women. STUDY DESIGN: In this prospective randomized study, we randomly assigned 58 healthy postmenopausal women to CEE (0.625 mg/day) plus MPA (2.5 mg/day) (CEE + MPA) or tibolone (2.5 mg/day). The serum levels of CRP at 3 months after starting treatment were compared with baseline values for both therapies. RESULTS: After 3 months of treatment the median CRP levels increased by 29% in the CEE + MPA group and by 5% in the tibolone group. But, these changes did not have statistical significance (P=0.15, P=0.06, respectively). CONCLUSIONS: Our findings show that neither tibolone nor CEE + MPA caused significant changes in serum CRP levels in postmenopausal women. The potential impact of hormone therapy on serum CRP levels should be investigated in ongoing clinical trials. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/16369811/Short_term_effects_of_hormone_therapy_on_serum_C_reactive_protein_levels_in_postmenopausal_women_ L2 - https://dx.doi.org/10.1007/s00404-005-0111-1 DB - PRIME DP - Unbound Medicine ER -