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Safety and efficacy of pediculicides for head lice.
Expert Opin Drug Saf. 2006 Jan; 5(1):169-79.EO

Abstract

Head lice infestation is a common and growing problem, primarily affecting school-aged children. There are growing numbers of treatment failures due to the emergence of treatment-resistant lice to the popular over-the-counter products that have been used for the past several decades. Resistance has also decreased the efficacy of lindane, a prescription pediculicide that has been commonly used for several generations. Malathion, recently reintroduced in the US as a prescription pediculicide, has been associated with some treatment resistance depending upon its formulation. Other insecticidal treatments, such as ivermectin, will have to be developed further, given the limited options presently available for the treatment of head lice. Given the number of anecdotal and market-driven reported studies on head lice, assessment of topical lice therapies requires standardised in vitro testing. Based on concerns about safety and decreasing efficacy due to resistance, a reassessment of the general topic of pediculicides for head lice is warranted.

Authors+Show Affiliations

Burkhart CG
Medical University of Ohio at Toledo, Department of Internal Medicine, 5600 Monroe Street, Suite 106-B, Sylvania OH 43560, USA. cgbakb@aol.com
Burkhart CN
No affiliation info available

MeSH

AnimalsChildChild, PreschoolDrug PrescriptionsHumansInsecticide ResistanceInsecticidesLice InfestationsNonprescription DrugsPediculusSafety

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16370965

Citation

Burkhart, Craig G., and Craig N. Burkhart. "Safety and Efficacy of Pediculicides for Head Lice." Expert Opinion On Drug Safety, vol. 5, no. 1, 2006, pp. 169-79.
Burkhart CG, Burkhart CN. Safety and efficacy of pediculicides for head lice. Expert Opin Drug Saf. 2006;5(1):169-79.
Burkhart, C. G., & Burkhart, C. N. (2006). Safety and efficacy of pediculicides for head lice. Expert Opinion On Drug Safety, 5(1), 169-79.
Burkhart CG, Burkhart CN. Safety and Efficacy of Pediculicides for Head Lice. Expert Opin Drug Saf. 2006;5(1):169-79. PubMed PMID: 16370965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficacy of pediculicides for head lice. AU - Burkhart,Craig G, AU - Burkhart,Craig N, PY - 2005/12/24/pubmed PY - 2006/3/15/medline PY - 2005/12/24/entrez SP - 169 EP - 79 JF - Expert opinion on drug safety JO - Expert Opin Drug Saf VL - 5 IS - 1 N2 - Head lice infestation is a common and growing problem, primarily affecting school-aged children. There are growing numbers of treatment failures due to the emergence of treatment-resistant lice to the popular over-the-counter products that have been used for the past several decades. Resistance has also decreased the efficacy of lindane, a prescription pediculicide that has been commonly used for several generations. Malathion, recently reintroduced in the US as a prescription pediculicide, has been associated with some treatment resistance depending upon its formulation. Other insecticidal treatments, such as ivermectin, will have to be developed further, given the limited options presently available for the treatment of head lice. Given the number of anecdotal and market-driven reported studies on head lice, assessment of topical lice therapies requires standardised in vitro testing. Based on concerns about safety and decreasing efficacy due to resistance, a reassessment of the general topic of pediculicides for head lice is warranted. SN - 1744-764X UR - https://www.unboundmedicine.com/medline/citation/16370965/Safety_and_efficacy_of_pediculicides_for_head_lice_ DB - PRIME DP - Unbound Medicine ER -