Tags

Type your tag names separated by a space and hit enter

A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder.
J Atten Disord. 2005 Aug; 9(1):275-89.JA

Abstract

Mixed amphetamine salts extended release (MAS XR; Adderall XR) and atomoxetine (Strattera) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study. Primary efficacy measure was the SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) behavioral rating scale. Changes in mean SKAMP deportment scores from baseline were significantly greater for MAS XR (n = 102) than for atomoxetine (n = 101) overall (-0.56 and -0.13, respectively; p < .0001) and at each week (p < .001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD.

Authors+Show Affiliations

Child Development Center, University of California, Irvine, CA 92612, USA. sbwigal@uci.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16371674

Citation

Wigal, Sharon B., et al. "A Laboratory School Comparison of Mixed Amphetamine Salts Extended Release (Adderall XR) and Atomoxetine (Strattera) in School-aged Children With Attention Deficit/hyperactivity Disorder." Journal of Attention Disorders, vol. 9, no. 1, 2005, pp. 275-89.
Wigal SB, McGough JJ, McCracken JT, et al. A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. J Atten Disord. 2005;9(1):275-89.
Wigal, S. B., McGough, J. J., McCracken, J. T., Biederman, J., Spencer, T. J., Posner, K. L., Wigal, T. L., Kollins, S. H., Clark, T. M., Mays, D. A., Zhang, Y., & Tulloch, S. J. (2005). A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. Journal of Attention Disorders, 9(1), 275-89.
Wigal SB, et al. A Laboratory School Comparison of Mixed Amphetamine Salts Extended Release (Adderall XR) and Atomoxetine (Strattera) in School-aged Children With Attention Deficit/hyperactivity Disorder. J Atten Disord. 2005;9(1):275-89. PubMed PMID: 16371674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. AU - Wigal,Sharon B, AU - McGough,James J, AU - McCracken,James T, AU - Biederman,Joseph, AU - Spencer,Thomas J, AU - Posner,Kelly L, AU - Wigal,Tim L, AU - Kollins,Scott H, AU - Clark,Tanya M, AU - Mays,David A, AU - Zhang,Yuxin, AU - Tulloch,Simon J, PY - 2005/12/24/pubmed PY - 2006/3/4/medline PY - 2005/12/24/entrez SP - 275 EP - 89 JF - Journal of attention disorders JO - J Atten Disord VL - 9 IS - 1 N2 - Mixed amphetamine salts extended release (MAS XR; Adderall XR) and atomoxetine (Strattera) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study. Primary efficacy measure was the SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) behavioral rating scale. Changes in mean SKAMP deportment scores from baseline were significantly greater for MAS XR (n = 102) than for atomoxetine (n = 101) overall (-0.56 and -0.13, respectively; p < .0001) and at each week (p < .001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD. SN - 1087-0547 UR - https://www.unboundmedicine.com/medline/citation/16371674/A_laboratory_school_comparison_of_mixed_amphetamine_salts_extended_release__Adderall_XR__and_atomoxetine__Strattera__in_school_aged_children_with_attention_deficit/hyperactivity_disorder_ L2 - https://journals.sagepub.com/doi/10.1177/1087054705281121?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -