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Protective effect of Spirulina against doxorubicin-induced cardiotoxicity.
Phytother Res 2005; 19(12):1030-7PR

Abstract

The generation of reactive oxygen species and mitochondrial dysfunction has been implicated in doxorubicin (DOX)-induced cardiotoxicity. The aim of the present study was to determine whether Spirulina, a blue-green algae, could serve as a cardioprotective agent during DOX treatment in a mouse model. Mice were treated with DOX (4 mg/kg bw, intraperitoneally), weekly, for 4 weeks. Spirulina was administered orally for 3 days twice daily, then for 7 weeks along with the four equal injections of DOX. Cardiotoxicity was assessed, at 3 weeks after the end of the DOX-treatment period, by mortality, volume of ascites, liver congestion, oxidative stress and ultrastructural changes of heart tissue. The DOX-treated animals showed higher mortality (53%) and more ascites. Myocardial damage, as assessed by ultrastructural changes, showed loss of myofibrils, cytoplasmic vacuolization and mitochondrial swelling. Myocardial superoxide dismutase and glutathione peroxidase activities were decreased and lipid peroxidation was increased. Pretreatment with Spirulina significantly protected the mice from DOX-induced cardiotoxic effects as evidenced from lower mortality (26%), less ascites, lower levels of lipid peroxidation, normalization of antioxidant enzymes and ultrastructural studies showing minimal damage to the heart. In vitro cytotoxic studies using ovarian cancer cells demonstrated that Spirulina did not compromise the anti-tumor activity of doxorubicin. These results suggest that Spirulina has a protective effect against cardiotoxicity induced by DOX and it may, therefore, improve the therapeutic index of DOX.

Authors+Show Affiliations

Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16372368

Citation

Khan, Mahmood, et al. "Protective Effect of Spirulina Against Doxorubicin-induced Cardiotoxicity." Phytotherapy Research : PTR, vol. 19, no. 12, 2005, pp. 1030-7.
Khan M, Shobha JC, Mohan IK, et al. Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytother Res. 2005;19(12):1030-7.
Khan, M., Shobha, J. C., Mohan, I. K., Naidu, M. U., Sundaram, C., Singh, S., ... Kutala, V. K. (2005). Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytotherapy Research : PTR, 19(12), pp. 1030-7.
Khan M, et al. Protective Effect of Spirulina Against Doxorubicin-induced Cardiotoxicity. Phytother Res. 2005;19(12):1030-7. PubMed PMID: 16372368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. AU - Khan,Mahmood, AU - Shobha,Jagdish Chandra, AU - Mohan,Iyyapu Krishna, AU - Naidu,Madireddi Umamaheswara Rao, AU - Sundaram,Challa, AU - Singh,Shashi, AU - Kuppusamy,Periannan, AU - Kutala,Vijay Kumar, PY - 2005/12/24/pubmed PY - 2006/3/18/medline PY - 2005/12/24/entrez SP - 1030 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 19 IS - 12 N2 - The generation of reactive oxygen species and mitochondrial dysfunction has been implicated in doxorubicin (DOX)-induced cardiotoxicity. The aim of the present study was to determine whether Spirulina, a blue-green algae, could serve as a cardioprotective agent during DOX treatment in a mouse model. Mice were treated with DOX (4 mg/kg bw, intraperitoneally), weekly, for 4 weeks. Spirulina was administered orally for 3 days twice daily, then for 7 weeks along with the four equal injections of DOX. Cardiotoxicity was assessed, at 3 weeks after the end of the DOX-treatment period, by mortality, volume of ascites, liver congestion, oxidative stress and ultrastructural changes of heart tissue. The DOX-treated animals showed higher mortality (53%) and more ascites. Myocardial damage, as assessed by ultrastructural changes, showed loss of myofibrils, cytoplasmic vacuolization and mitochondrial swelling. Myocardial superoxide dismutase and glutathione peroxidase activities were decreased and lipid peroxidation was increased. Pretreatment with Spirulina significantly protected the mice from DOX-induced cardiotoxic effects as evidenced from lower mortality (26%), less ascites, lower levels of lipid peroxidation, normalization of antioxidant enzymes and ultrastructural studies showing minimal damage to the heart. In vitro cytotoxic studies using ovarian cancer cells demonstrated that Spirulina did not compromise the anti-tumor activity of doxorubicin. These results suggest that Spirulina has a protective effect against cardiotoxicity induced by DOX and it may, therefore, improve the therapeutic index of DOX. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16372368/Protective_effect_of_Spirulina_against_doxorubicin_induced_cardiotoxicity_ L2 - https://doi.org/10.1002/ptr.1783 DB - PRIME DP - Unbound Medicine ER -