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Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers.

Abstract

The aim of this study was to determine the therapeutic efficacy of marigold (Calendula officinalis) extract on the epithelialization of lower leg venous ulcers. The experiment was carried out in 34 patients with venous leg ulcers. The patients were divided into two groups. In the first (experimental) group, patients were treated with an ointment containing marigold extract, which was prepared in an apparatus devised by Soxleth and was incorporated into a neutral base. Twenty-one patients with 33 venous ulcers were treated. Therapy was applied twice a day for 3 weeks. The second group was a control group that consisted of 13 patients with 22 venous ulcers. In the control group, saline solution dressings were applied to ulcers for 3 weeks. In the experimental group the total surface of all the ulcers at the beginning of the therapy was 67,544 mm2. After the third week the total surface of all the ulcers was 39,373 mm2 (a decrease of 41.71%). In seven patients, complete epithelialization was achieved. In the control group the total surface of all the ulcers at the beginning of the therapy was 69,722 mm2. After the third week the total surface of all the ulcers was 58,743 mm2 (a decrease of 14.52%). In four patients, complete epithelialization was achieved. There was a statistically significant acceleration of wound healing in the experimental group (p < 0.05). The results obtained are preliminary, but they suggest the positive effects of the ointment with marigold extract on venous ulcer epithelialization.

Authors+Show Affiliations

,

Clinical Center, Dermatovenereological Clinic, Novi Sad, Serbia and Montenegro. mamatic@ptt.yu

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Source

MeSH

Administration, Topical
Aged
Calendula
Clinical Trials as Topic
Female
Humans
Leg
Male
Occlusive Dressings
Ointments
Phytotherapy
Plant Extracts
Plant Preparations
Time Factors
Treatment Outcome
Varicose Ulcer
Wound Healing

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16372475

Citation

Duran, V, et al. "Results of the Clinical Examination of an Ointment With Marigold (Calendula Officinalis) Extract in the Treatment of Venous Leg Ulcers." International Journal of Tissue Reactions, vol. 27, no. 3, 2005, pp. 101-6.
Duran V, Matic M, Jovanovć M, et al. Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React. 2005;27(3):101-6.
Duran, V., Matic, M., Jovanovć, M., Mimica, N., Gajinov, Z., Poljacki, M., & Boza, P. (2005). Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. International Journal of Tissue Reactions, 27(3), pp. 101-6.
Duran V, et al. Results of the Clinical Examination of an Ointment With Marigold (Calendula Officinalis) Extract in the Treatment of Venous Leg Ulcers. Int J Tissue React. 2005;27(3):101-6. PubMed PMID: 16372475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. AU - Duran,V, AU - Matic,M, AU - Jovanovć,M, AU - Mimica,N, AU - Gajinov,Z, AU - Poljacki,M, AU - Boza,P, PY - 2005/12/24/pubmed PY - 2006/1/24/medline PY - 2005/12/24/entrez SP - 101 EP - 6 JF - International journal of tissue reactions JO - Int J Tissue React VL - 27 IS - 3 N2 - The aim of this study was to determine the therapeutic efficacy of marigold (Calendula officinalis) extract on the epithelialization of lower leg venous ulcers. The experiment was carried out in 34 patients with venous leg ulcers. The patients were divided into two groups. In the first (experimental) group, patients were treated with an ointment containing marigold extract, which was prepared in an apparatus devised by Soxleth and was incorporated into a neutral base. Twenty-one patients with 33 venous ulcers were treated. Therapy was applied twice a day for 3 weeks. The second group was a control group that consisted of 13 patients with 22 venous ulcers. In the control group, saline solution dressings were applied to ulcers for 3 weeks. In the experimental group the total surface of all the ulcers at the beginning of the therapy was 67,544 mm2. After the third week the total surface of all the ulcers was 39,373 mm2 (a decrease of 41.71%). In seven patients, complete epithelialization was achieved. In the control group the total surface of all the ulcers at the beginning of the therapy was 69,722 mm2. After the third week the total surface of all the ulcers was 58,743 mm2 (a decrease of 14.52%). In four patients, complete epithelialization was achieved. There was a statistically significant acceleration of wound healing in the experimental group (p < 0.05). The results obtained are preliminary, but they suggest the positive effects of the ointment with marigold extract on venous ulcer epithelialization. SN - 0250-0868 UR - https://www.unboundmedicine.com/medline/citation/16372475/Results_of_the_clinical_examination_of_an_ointment_with_marigold__Calendula_officinalis__extract_in_the_treatment_of_venous_leg_ulcers_ L2 - https://ClinicalTrials.gov/search/term=16372475 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -