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Relationship of body fat distribution by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women.
Gynecol Endocrinol. 2005 Nov; 21(5):295-301.GE

Abstract

OBJECTIVE

To correlate body fat distribution evaluated by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance and lipid profile in obese and non-obese postmenopausal women.

METHODS

We studied 40 obese and 47 non-obese postmenopausal women, assessing obesity by measuring waist circumference and fat tissue using dual-energy X-ray absorptiometry and ultrasonography, and examining their correlation with metabolic parameters: insulin resistance as determined by the homeostasis model assessment technique (HOMA-IR) and lipid profile including triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein, lipoprotein(a) (Lp(a)) and apoplipoprotein A-I (Apo A-I).

RESULTS

There was no difference in lipid profile between the two groups. Insulin resistance was the metabolic disturbance of highest prevalence in the obese group, evaluated by HOMA-IR (obese: 3.38 +/- 2.2; non-obese: 1.20 +/- 0.7; p < 0.001). Obesity was not a confounding factor in linear regression analyses among HOMA-IR, HDL-C, TG, Lp(a), Apo A-I and the methods used to measure body fat distribution. Waist circumference was the method that best explained HOMA-IR (R(2) = 34.9%, p < 0.001) and TG concentration (R(2) = 10.9%, p = 0.002). HDL-C presented a positive association with subcutaneous fat evaluated by ultrasonography (R(2) = 12.5%, p < 0.001). Obesity was a confounding factor in multiple regression analyses between TC and LDL-C, when related to abdominal fat evaluated by ultrasonography, and resulted in a positive association among the obese and a negative association among the non-obese women. The sensibility of this method was related to the quantity of fat in the visceral region.

CONCLUSIONS

Waist circumference showed the highest association with insulin resistance. Fat distribution evaluated by dual-energy X-ray absorptiometry and ultrasound was also associated with insulin resistance, but with lower intensity. The relationship of visceral fat distribution evaluated by ultrasound to TC cholesterol and LDL-C showed opposed results between obese and non-obese menopausal women.

Links

Publisher Full Text

Authors+Show Affiliations

dos Santos RE
Department of Obstetrics and Gynecology, Division of Endocrinology Gynecology, School of Medicine, Santa Casa de São Paulo, Brazil.
Aldrighi JM
No affiliation info available
Lanz JR
No affiliation info available
Ferezin PC
No affiliation info available
Marone MM
No affiliation info available

MeSH

Absorptiometry, PhotonApolipoprotein A-IBody Fat DistributionBody Weights and MeasuresCholesterolCholesterol, HDLCholesterol, LDLFemaleHomeostasisHumansInsulin ResistanceLinear ModelsLipidsLipoprotein(a)Lipoproteins, VLDLMiddle AgedObesityPostmenopauseTriglyceridesUltrasonography

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16373250

Citation

dos Santos, Roberto Euzebio, et al. "Relationship of Body Fat Distribution By Waist Circumference, Dual-energy X-ray Absorptiometry and Ultrasonography to Insulin Resistance By Homeostasis Model Assessment and Lipid Profile in Obese and Non-obese Postmenopausal Women." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 21, no. 5, 2005, pp. 295-301.
dos Santos RE, Aldrighi JM, Lanz JR, et al. Relationship of body fat distribution by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. Gynecol Endocrinol. 2005;21(5):295-301.
dos Santos, R. E., Aldrighi, J. M., Lanz, J. R., Ferezin, P. C., & Marone, M. M. (2005). Relationship of body fat distribution by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 21(5), 295-301.
dos Santos RE, et al. Relationship of Body Fat Distribution By Waist Circumference, Dual-energy X-ray Absorptiometry and Ultrasonography to Insulin Resistance By Homeostasis Model Assessment and Lipid Profile in Obese and Non-obese Postmenopausal Women. Gynecol Endocrinol. 2005;21(5):295-301. PubMed PMID: 16373250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of body fat distribution by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. AU - dos Santos,Roberto Euzebio, AU - Aldrighi,José Mendes, AU - Lanz,José Ramón, AU - Ferezin,Pollyanna C, AU - Marone,Marilia M S, PY - 2005/12/24/pubmed PY - 2006/4/7/medline PY - 2005/12/24/entrez SP - 295 EP - 301 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 21 IS - 5 N2 - OBJECTIVE: To correlate body fat distribution evaluated by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance and lipid profile in obese and non-obese postmenopausal women. METHODS: We studied 40 obese and 47 non-obese postmenopausal women, assessing obesity by measuring waist circumference and fat tissue using dual-energy X-ray absorptiometry and ultrasonography, and examining their correlation with metabolic parameters: insulin resistance as determined by the homeostasis model assessment technique (HOMA-IR) and lipid profile including triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein, lipoprotein(a) (Lp(a)) and apoplipoprotein A-I (Apo A-I). RESULTS: There was no difference in lipid profile between the two groups. Insulin resistance was the metabolic disturbance of highest prevalence in the obese group, evaluated by HOMA-IR (obese: 3.38 +/- 2.2; non-obese: 1.20 +/- 0.7; p < 0.001). Obesity was not a confounding factor in linear regression analyses among HOMA-IR, HDL-C, TG, Lp(a), Apo A-I and the methods used to measure body fat distribution. Waist circumference was the method that best explained HOMA-IR (R(2) = 34.9%, p < 0.001) and TG concentration (R(2) = 10.9%, p = 0.002). HDL-C presented a positive association with subcutaneous fat evaluated by ultrasonography (R(2) = 12.5%, p < 0.001). Obesity was a confounding factor in multiple regression analyses between TC and LDL-C, when related to abdominal fat evaluated by ultrasonography, and resulted in a positive association among the obese and a negative association among the non-obese women. The sensibility of this method was related to the quantity of fat in the visceral region. CONCLUSIONS: Waist circumference showed the highest association with insulin resistance. Fat distribution evaluated by dual-energy X-ray absorptiometry and ultrasound was also associated with insulin resistance, but with lower intensity. The relationship of visceral fat distribution evaluated by ultrasound to TC cholesterol and LDL-C showed opposed results between obese and non-obese menopausal women. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16373250/Relationship_of_body_fat_distribution_by_waist_circumference_dual_energy_X_ray_absorptiometry_and_ultrasonography_to_insulin_resistance_by_homeostasis_model_assessment_and_lipid_profile_in_obese_and_non_obese_postmenopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590500361937 DB - PRIME DP - Unbound Medicine ER -