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Substantia nigra tangles are related to gait impairment in older persons.
Ann Neurol. 2006 Jan; 59(1):166-73.AN

Abstract

OBJECTIVE

Parkinsonian signs, especially gait impairment, are common and associated with morbidity and mortality in older persons. Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia.

METHODS

We studied 86 deceased older Catholic clergy without idiopathic Parkinson's disease from the Religious Order Study, a longitudinal clinical-pathological study. Mean age at death was 85.3 years. Signs of gait disturbance, bradykinesia, rigidity, and tremor were assessed proximate to death using a modified Unified Parkinson's Disease Rating Scale. Forty-micrometer paraffin-embedded sections of substantia nigra were bleached before tau immunohistochemistry and the optical disector was used to count NFTs. We used multivariable linear regression to examine parkinsonian signs as a function of nigra NFTs, controlling for age, sex, education, and cortical NFTs.

RESULTS

Substantia nigra NFTs were present in 67 of 86 persons (77.9%). After controlling for age, sex, education, and cortical NFTs, nigra NFTs were related to gait impairment (p < 0.001), but not bradykinesia, rigidity, or tremor. Results were not confounded by dementia, Braak score, neuroleptic medication, cerebral infarcts, or Lewy bodies.

INTERPRETATION

NFTs in the substantia nigra are associated with gait impairment in older persons with and without dementia.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina Street, Chicago, IL, USA. julie_a_schneider@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16374822

Citation

Schneider, Julie A., et al. "Substantia Nigra Tangles Are Related to Gait Impairment in Older Persons." Annals of Neurology, vol. 59, no. 1, 2006, pp. 166-73.
Schneider JA, Li JL, Li Y, et al. Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol. 2006;59(1):166-73.
Schneider, J. A., Li, J. L., Li, Y., Wilson, R. S., Kordower, J. H., & Bennett, D. A. (2006). Substantia nigra tangles are related to gait impairment in older persons. Annals of Neurology, 59(1), 166-73.
Schneider JA, et al. Substantia Nigra Tangles Are Related to Gait Impairment in Older Persons. Ann Neurol. 2006;59(1):166-73. PubMed PMID: 16374822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Substantia nigra tangles are related to gait impairment in older persons. AU - Schneider,Julie A, AU - Li,Jia-liang, AU - Li,Yan, AU - Wilson,Robert S, AU - Kordower,Jeffrey H, AU - Bennett,David A, PY - 2005/12/24/pubmed PY - 2006/3/24/medline PY - 2005/12/24/entrez SP - 166 EP - 73 JF - Annals of neurology JO - Ann Neurol VL - 59 IS - 1 N2 - OBJECTIVE: Parkinsonian signs, especially gait impairment, are common and associated with morbidity and mortality in older persons. Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia. METHODS: We studied 86 deceased older Catholic clergy without idiopathic Parkinson's disease from the Religious Order Study, a longitudinal clinical-pathological study. Mean age at death was 85.3 years. Signs of gait disturbance, bradykinesia, rigidity, and tremor were assessed proximate to death using a modified Unified Parkinson's Disease Rating Scale. Forty-micrometer paraffin-embedded sections of substantia nigra were bleached before tau immunohistochemistry and the optical disector was used to count NFTs. We used multivariable linear regression to examine parkinsonian signs as a function of nigra NFTs, controlling for age, sex, education, and cortical NFTs. RESULTS: Substantia nigra NFTs were present in 67 of 86 persons (77.9%). After controlling for age, sex, education, and cortical NFTs, nigra NFTs were related to gait impairment (p < 0.001), but not bradykinesia, rigidity, or tremor. Results were not confounded by dementia, Braak score, neuroleptic medication, cerebral infarcts, or Lewy bodies. INTERPRETATION: NFTs in the substantia nigra are associated with gait impairment in older persons with and without dementia. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16374822/Substantia_nigra_tangles_are_related_to_gait_impairment_in_older_persons_ L2 - https://doi.org/10.1002/ana.20723 DB - PRIME DP - Unbound Medicine ER -