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Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T.
J Magn Reson Imaging. 2006 Feb; 23(2):130-4.JM

Abstract

PURPOSE

To measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased-array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ).

MATERIALS AND METHODS

ADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer. Additionally, for nine asymptomatic volunteers, ADC values were determined for apparently normal central gland and PZ. A single-shot EPI diffusion-weighted imaging (DWI) technique with b = 0 and 500 seconds/mm2 was employed.

RESULTS

ADC values were significantly lower for tumor (1.38 +/- 0.32 x 10(-3) mm2/second) than for patient PZ (1.95 +/- 0.50 x 10(-3) mm2/second, P < 0.001) and volunteer PZ (1.60 +/- 0.25 x 10(-3) mm2/second, P = 0.031). A considerable overlap of ADC values was noted between patient tissue types.

CONCLUSION

DWI of the prostate at 3.0T in conjunction with a phased-array coil and parallel imaging allows ADC calculation of the prostate. ADC values were lower for tumors compared to normal-appearing PZ; however, there was considerable intersubject variability.

Authors+Show Affiliations

Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull, UK. m.d.pickles@medschool.hull.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16374882

Citation

Pickles, Martin D., et al. "Diffusion-weighted Imaging of Normal and Malignant Prostate Tissue at 3.0T." Journal of Magnetic Resonance Imaging : JMRI, vol. 23, no. 2, 2006, pp. 130-4.
Pickles MD, Gibbs P, Sreenivas M, et al. Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T. J Magn Reson Imaging. 2006;23(2):130-4.
Pickles, M. D., Gibbs, P., Sreenivas, M., & Turnbull, L. W. (2006). Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T. Journal of Magnetic Resonance Imaging : JMRI, 23(2), 130-4.
Pickles MD, et al. Diffusion-weighted Imaging of Normal and Malignant Prostate Tissue at 3.0T. J Magn Reson Imaging. 2006;23(2):130-4. PubMed PMID: 16374882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T. AU - Pickles,Martin D, AU - Gibbs,Peter, AU - Sreenivas,Muthyala, AU - Turnbull,Lindsay W, PY - 2005/12/24/pubmed PY - 2006/5/4/medline PY - 2005/12/24/entrez SP - 130 EP - 4 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 23 IS - 2 N2 - PURPOSE: To measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased-array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ). MATERIALS AND METHODS: ADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer. Additionally, for nine asymptomatic volunteers, ADC values were determined for apparently normal central gland and PZ. A single-shot EPI diffusion-weighted imaging (DWI) technique with b = 0 and 500 seconds/mm2 was employed. RESULTS: ADC values were significantly lower for tumor (1.38 +/- 0.32 x 10(-3) mm2/second) than for patient PZ (1.95 +/- 0.50 x 10(-3) mm2/second, P < 0.001) and volunteer PZ (1.60 +/- 0.25 x 10(-3) mm2/second, P = 0.031). A considerable overlap of ADC values was noted between patient tissue types. CONCLUSION: DWI of the prostate at 3.0T in conjunction with a phased-array coil and parallel imaging allows ADC calculation of the prostate. ADC values were lower for tumors compared to normal-appearing PZ; however, there was considerable intersubject variability. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/16374882/Diffusion_weighted_imaging_of_normal_and_malignant_prostate_tissue_at_3_0T_ L2 - https://doi.org/10.1002/jmri.20477 DB - PRIME DP - Unbound Medicine ER -