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Influence of cyclodextrin complexation on piroxicam gel formulations.
Acta Pharm. 2005 Sep; 55(3):223-36.AP

Abstract

The aim of this work was to evaluate the role of cyclodextrins in topical drug formulations. Solid piroxicam (PX) complexes with beta-cyclodextrin (beta-CD) and randomly methylated beta-cyclodextrin (RAMEB) were prepared by freeze-drying and characterized using differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transform infrared spectroscopy (FTIR) and near infrared spectroscopy (NIR). A physical mixture of PX and cyclodextrins was characterized by enhanced dissolution properties compared to the dissolution profile of the pure drug due to in situ complex formation. Formation of the PX-cyclodextrin inclusion complex additionally improved the drug dissolution properties. Influence of CDs on drug permeation from the water dispersion and the prepared hydroxypropyl methylcellulose (HPMC) gels was investigated. Permeation of the drug involved three consecutive processes: dissolution of the solid phase, diffusion across the swollen polymer matrix and drug permeation through the membrane. Complexation increased PX diffusion by increasing the amount of diffusible species in the donor phase. Slower drug diffusion through the HPMC matrix was the rate limiting step in the overall diffusion process. Possible interaction between the hydrophilic polymer and cyclodextrin may result in physicochemical changes, especially in a change of rheological parameters.

Authors+Show Affiliations

Department of Pharmaceutics Faculty of Pharmacy and Biochemistry University of Zagreb, Zagreb, Croatia. mjug@pharma.hrNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16375834

Citation

Jug, Mario, et al. "Influence of Cyclodextrin Complexation On Piroxicam Gel Formulations." Acta Pharmaceutica (Zagreb, Croatia), vol. 55, no. 3, 2005, pp. 223-36.
Jug M, Bećirević-Laćan M, Kwokal A, et al. Influence of cyclodextrin complexation on piroxicam gel formulations. Acta Pharm. 2005;55(3):223-36.
Jug, M., Bećirević-Laćan, M., Kwokal, A., & Cetina-Cizmek, B. (2005). Influence of cyclodextrin complexation on piroxicam gel formulations. Acta Pharmaceutica (Zagreb, Croatia), 55(3), 223-36.
Jug M, et al. Influence of Cyclodextrin Complexation On Piroxicam Gel Formulations. Acta Pharm. 2005;55(3):223-36. PubMed PMID: 16375834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of cyclodextrin complexation on piroxicam gel formulations. AU - Jug,Mario, AU - Bećirević-Laćan,Mira, AU - Kwokal,Ana, AU - Cetina-Cizmek,Biserka, PY - 2005/12/27/pubmed PY - 2006/1/21/medline PY - 2005/12/27/entrez SP - 223 EP - 36 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 55 IS - 3 N2 - The aim of this work was to evaluate the role of cyclodextrins in topical drug formulations. Solid piroxicam (PX) complexes with beta-cyclodextrin (beta-CD) and randomly methylated beta-cyclodextrin (RAMEB) were prepared by freeze-drying and characterized using differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transform infrared spectroscopy (FTIR) and near infrared spectroscopy (NIR). A physical mixture of PX and cyclodextrins was characterized by enhanced dissolution properties compared to the dissolution profile of the pure drug due to in situ complex formation. Formation of the PX-cyclodextrin inclusion complex additionally improved the drug dissolution properties. Influence of CDs on drug permeation from the water dispersion and the prepared hydroxypropyl methylcellulose (HPMC) gels was investigated. Permeation of the drug involved three consecutive processes: dissolution of the solid phase, diffusion across the swollen polymer matrix and drug permeation through the membrane. Complexation increased PX diffusion by increasing the amount of diffusible species in the donor phase. Slower drug diffusion through the HPMC matrix was the rate limiting step in the overall diffusion process. Possible interaction between the hydrophilic polymer and cyclodextrin may result in physicochemical changes, especially in a change of rheological parameters. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/16375834/Influence_of_cyclodextrin_complexation_on_piroxicam_gel_formulations_ L2 - https://antibodies.cancer.gov/detail/CPTC-CTLA4-1 DB - PRIME DP - Unbound Medicine ER -