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Assessment of Albizia zygia gum as a binding agent in tablet formulations.
Acta Pharm. 2005 Sep; 55(3):263-76.AP

Abstract

Albizia gum has been evaluated as a binding agent in tablet formulations in comparison with gelatin BP. Compressional properties were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters, while the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets. Drug release properties of the tablets were assessed using disintegration time and dissolution time as assessment parameters. Formulations containing Albizia gum as a binding agent show a faster onset and higher amount of plastic deformation under compression pressure than those containing gelatin. The crushing strength, disintegration and dissolution times of the tablets increased with increased binder concentration while their friability decreased. Albizia gum produced tablets with better mechanical properties and longer disintegration and dissolution times than those containing gelatin BP. This suggests that Albizia gum could be useful as a binding agent especially when high mechanical strength and slower release rates are desired.

Authors+Show Affiliations

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy University of Ibadan, Ibadan, Nigeria. pejuodeku@yahoo.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16375837

Citation

Odeku, Oluwatoyin A.. "Assessment of Albizia Zygia Gum as a Binding Agent in Tablet Formulations." Acta Pharmaceutica (Zagreb, Croatia), vol. 55, no. 3, 2005, pp. 263-76.
Odeku OA. Assessment of Albizia zygia gum as a binding agent in tablet formulations. Acta Pharm. 2005;55(3):263-76.
Odeku, O. A. (2005). Assessment of Albizia zygia gum as a binding agent in tablet formulations. Acta Pharmaceutica (Zagreb, Croatia), 55(3), 263-76.
Odeku OA. Assessment of Albizia Zygia Gum as a Binding Agent in Tablet Formulations. Acta Pharm. 2005;55(3):263-76. PubMed PMID: 16375837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of Albizia zygia gum as a binding agent in tablet formulations. A1 - Odeku,Oluwatoyin A, PY - 2005/12/27/pubmed PY - 2006/1/21/medline PY - 2005/12/27/entrez SP - 263 EP - 76 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 55 IS - 3 N2 - Albizia gum has been evaluated as a binding agent in tablet formulations in comparison with gelatin BP. Compressional properties were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters, while the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets. Drug release properties of the tablets were assessed using disintegration time and dissolution time as assessment parameters. Formulations containing Albizia gum as a binding agent show a faster onset and higher amount of plastic deformation under compression pressure than those containing gelatin. The crushing strength, disintegration and dissolution times of the tablets increased with increased binder concentration while their friability decreased. Albizia gum produced tablets with better mechanical properties and longer disintegration and dissolution times than those containing gelatin BP. This suggests that Albizia gum could be useful as a binding agent especially when high mechanical strength and slower release rates are desired. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/16375837/Assessment_of_Albizia_zygia_gum_as_a_binding_agent_in_tablet_formulations_ DB - PRIME DP - Unbound Medicine ER -