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Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders.
Brain Dev. 2006 Jun; 28(5):281-6.BD

Abstract

To elucidate an effective therapeutic strategy for 'ESES syndrome', epilepsy with electrical status epilepticus during slow sleep (ESES) and its related epileptic disorders, we studied the effect of treatment on the EEG pattern of continuous spike-waves during slow wave sleep (CSWS) in 15 afflicted patients. Basically performed in the following order, the employed therapies included (1) high-dose valproate (VPA) therapy (serum level >100 microg/ml); (2) a combination therapy of VPA and ethosuximide (ESM); (3) short cycles of high-dose diazepam (oral or intrarectal DZP, 0.5-1 mg/kg per day for 6-7 days); and (4) intramuscular synthetic ACTH-Z therapy (0.01-0.04 mg/kg per day for 11-43 days). Regarding the initial EEG effect, a remission of CSWS was achieved by high-dose VPA therapy in 7 of 15 trials (47%), by the combination therapy of VPA and ESM in 3/7 trials (43%), by short cycles of high-dose DZP in 2/4 trials (50%), and by ACTH-Z therapy in 2/5 trials (40%). A permanent remission of ESES syndrome was achieved by high-dose VPA therapy and/or combination therapy of VPA and ESM in 10 patients (67%). The effects of short cycles of high-dose DZP and ACTH-Z therapy were at best temporary. Our strategy for the treatment of ESES syndrome is therefore considered valid.

Authors+Show Affiliations

Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Okayama University Hospital, Okayama 700-8558, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

16376508

Citation

Inutsuka, Miki, et al. "Treatment of Epilepsy With Electrical Status Epilepticus During Slow Sleep and Its Related Disorders." Brain & Development, vol. 28, no. 5, 2006, pp. 281-6.
Inutsuka M, Kobayashi K, Oka M, et al. Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain Dev. 2006;28(5):281-6.
Inutsuka, M., Kobayashi, K., Oka, M., Hattori, J., & Ohtsuka, Y. (2006). Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain & Development, 28(5), 281-6.
Inutsuka M, et al. Treatment of Epilepsy With Electrical Status Epilepticus During Slow Sleep and Its Related Disorders. Brain Dev. 2006;28(5):281-6. PubMed PMID: 16376508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. AU - Inutsuka,Miki, AU - Kobayashi,Katsuhiro, AU - Oka,Makio, AU - Hattori,Junri, AU - Ohtsuka,Yoko, Y1 - 2006/01/10/ PY - 2005/03/28/received PY - 2005/09/03/revised PY - 2005/09/21/accepted PY - 2005/12/27/pubmed PY - 2006/7/27/medline PY - 2005/12/27/entrez SP - 281 EP - 6 JF - Brain & development JO - Brain Dev VL - 28 IS - 5 N2 - To elucidate an effective therapeutic strategy for 'ESES syndrome', epilepsy with electrical status epilepticus during slow sleep (ESES) and its related epileptic disorders, we studied the effect of treatment on the EEG pattern of continuous spike-waves during slow wave sleep (CSWS) in 15 afflicted patients. Basically performed in the following order, the employed therapies included (1) high-dose valproate (VPA) therapy (serum level >100 microg/ml); (2) a combination therapy of VPA and ethosuximide (ESM); (3) short cycles of high-dose diazepam (oral or intrarectal DZP, 0.5-1 mg/kg per day for 6-7 days); and (4) intramuscular synthetic ACTH-Z therapy (0.01-0.04 mg/kg per day for 11-43 days). Regarding the initial EEG effect, a remission of CSWS was achieved by high-dose VPA therapy in 7 of 15 trials (47%), by the combination therapy of VPA and ESM in 3/7 trials (43%), by short cycles of high-dose DZP in 2/4 trials (50%), and by ACTH-Z therapy in 2/5 trials (40%). A permanent remission of ESES syndrome was achieved by high-dose VPA therapy and/or combination therapy of VPA and ESM in 10 patients (67%). The effects of short cycles of high-dose DZP and ACTH-Z therapy were at best temporary. Our strategy for the treatment of ESES syndrome is therefore considered valid. SN - 0387-7604 UR - https://www.unboundmedicine.com/medline/citation/16376508/Treatment_of_epilepsy_with_electrical_status_epilepticus_during_slow_sleep_and_its_related_disorders_ DB - PRIME DP - Unbound Medicine ER -