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Ultrahigh resolution optical coherence tomography in macular dystrophy.
Am J Ophthalmol 2005; 140(6):976-983AJ

Abstract

PURPOSE

To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT).

DESIGN

Prospective observational case series.

METHODS

setting: Department of Ophthalmology and Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria. patients: Thirteen patients (23 eyes) with adult-onset foveomacular vitelliform dystrophy (AOFVD) and 14 patients (27 eyes) with Stargardt's disease (SD) or fundus flavimaculatus (FF).

OBSERVATIONS

Imaging using a compact, new generation UHR OCT system, achieving considerably improved visualization of intraretinal layers, especially the photoreceptor layer. main outcome measures: UHR OCT tomograms visualizing intraretinal differences in morphology of AOFVD and SD/FF as location and extension of deposits and loss of photoreceptors. Central foveal thickness defined as distance between internal limiting membrane and photoreceptors/retinal pigment epithelium interface.

RESULTS

Patients with AOFVD had a mostly intact photoreceptor layer, a central foveal thickness of 142 +/- 23 microm as well as subretinal deposits. Patients with SD generally had a diffuse degenerative change with a visible reduction in thickness of all intraretinal layers, resulting in a corresponding reduction of central foveal thickness (94 +/- 38 microm) and central loss of photoreceptors (PRs). Comparative central foveal thickness of patients with AOFVD and SD/FF was significantly different (P < .001). Patients with FF had pigment epithelial deposits and paracentral focal photoreceptor loss.

CONCLUSIONS

UHR OCT is a clinically feasible tool for examining intraretinal changes, in particular photoreceptor atrophy in macular dystrophies and, therefore, has the potential to be an adequate imaging system for monitoring the course of disease.

Authors+Show Affiliations

Department of Ophthalmology, Medical University of Vienna, Währinger Strasse 13, 1090 Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16376639

Citation

Wirtitsch, Matthias G., et al. "Ultrahigh Resolution Optical Coherence Tomography in Macular Dystrophy." American Journal of Ophthalmology, vol. 140, no. 6, 2005, pp. 976-983.
Wirtitsch MG, Ergun E, Hermann B, et al. Ultrahigh resolution optical coherence tomography in macular dystrophy. Am J Ophthalmol. 2005;140(6):976-983.
Wirtitsch, M. G., Ergun, E., Hermann, B., Unterhuber, A., Stur, M., Scholda, C., ... Drexler, W. (2005). Ultrahigh resolution optical coherence tomography in macular dystrophy. American Journal of Ophthalmology, 140(6), pp. 976-983.
Wirtitsch MG, et al. Ultrahigh Resolution Optical Coherence Tomography in Macular Dystrophy. Am J Ophthalmol. 2005;140(6):976-983. PubMed PMID: 16376639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrahigh resolution optical coherence tomography in macular dystrophy. AU - Wirtitsch,Matthias G, AU - Ergun,Erdem, AU - Hermann,Boris, AU - Unterhuber,Angelika, AU - Stur,Michael, AU - Scholda,Christoph, AU - Sattmann,Harald, AU - Ko,Tony H, AU - Fujimoto,James G, AU - Drexler,Wolfgang, PY - 2005/02/18/received PY - 2005/06/06/revised PY - 2005/06/11/accepted PY - 2005/12/27/pubmed PY - 2006/1/25/medline PY - 2005/12/27/entrez SP - 976 EP - 983 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 140 IS - 6 N2 - PURPOSE: To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT). DESIGN: Prospective observational case series. METHODS: setting: Department of Ophthalmology and Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria. patients: Thirteen patients (23 eyes) with adult-onset foveomacular vitelliform dystrophy (AOFVD) and 14 patients (27 eyes) with Stargardt's disease (SD) or fundus flavimaculatus (FF). OBSERVATIONS: Imaging using a compact, new generation UHR OCT system, achieving considerably improved visualization of intraretinal layers, especially the photoreceptor layer. main outcome measures: UHR OCT tomograms visualizing intraretinal differences in morphology of AOFVD and SD/FF as location and extension of deposits and loss of photoreceptors. Central foveal thickness defined as distance between internal limiting membrane and photoreceptors/retinal pigment epithelium interface. RESULTS: Patients with AOFVD had a mostly intact photoreceptor layer, a central foveal thickness of 142 +/- 23 microm as well as subretinal deposits. Patients with SD generally had a diffuse degenerative change with a visible reduction in thickness of all intraretinal layers, resulting in a corresponding reduction of central foveal thickness (94 +/- 38 microm) and central loss of photoreceptors (PRs). Comparative central foveal thickness of patients with AOFVD and SD/FF was significantly different (P < .001). Patients with FF had pigment epithelial deposits and paracentral focal photoreceptor loss. CONCLUSIONS: UHR OCT is a clinically feasible tool for examining intraretinal changes, in particular photoreceptor atrophy in macular dystrophies and, therefore, has the potential to be an adequate imaging system for monitoring the course of disease. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16376639/Ultrahigh_resolution_optical_coherence_tomography_in_macular_dystrophy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(05)00713-0 DB - PRIME DP - Unbound Medicine ER -