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Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects.
J Nat Prod. 2005 Dec; 68(12):1732-5.JN

Abstract

Five new sesquiterpene chromone derivatives, fukanefurochromones A-E (1-5), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).

Authors+Show Affiliations

Motai T
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
Kitanaka S
No affiliation info available

MeSH

ChromonesDrugs, Chinese HerbalEnzyme InhibitorsFerulaMacrophage ActivationMolecular StructureNitric OxideNitric Oxide Synthase Type IIPlant RootsPlants, MedicinalReverse Transcriptase Polymerase Chain ReactionSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16378364

Citation

Motai, Tsunetake, and Susumu Kitanaka. "Sesquiterpene Chromones From Ferula Fukanensis and Their Nitric Oxide Production Inhibitory Effects." Journal of Natural Products, vol. 68, no. 12, 2005, pp. 1732-5.
Motai T, Kitanaka S. Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects. J Nat Prod. 2005;68(12):1732-5.
Motai, T., & Kitanaka, S. (2005). Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects. Journal of Natural Products, 68(12), 1732-5.
Motai T, Kitanaka S. Sesquiterpene Chromones From Ferula Fukanensis and Their Nitric Oxide Production Inhibitory Effects. J Nat Prod. 2005;68(12):1732-5. PubMed PMID: 16378364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects. AU - Motai,Tsunetake, AU - Kitanaka,Susumu, PY - 2005/12/28/pubmed PY - 2006/1/19/medline PY - 2005/12/28/entrez SP - 1732 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 12 N2 - Five new sesquiterpene chromone derivatives, fukanefurochromones A-E (1-5), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16378364/Sesquiterpene_chromones_from_Ferula_fukanensis_and_their_nitric_oxide_production_inhibitory_effects_ DB - PRIME DP - Unbound Medicine ER -