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Stroke subtypes among young patients with systemic lupus erythematosus.
Am J Med 2005; 118(12):1415AJ

Abstract

PURPOSE

Systemic lupus erythematosus (lupus) is a systemic inflammatory disease associated with premature atherosclerosis, vasculitis, coagulopathy, and excessive incidence of stroke, especially among young patients. Little is known about subtypes of stroke in lupus.

METHODS

A 20% sample of all the hospitalizations in the United States in the years 2001 and 2002 (N approximately 15 million) were analyzed to identify hospitalizations of young patients (age < or =50 years) with systemic lupus erythematosus (n=25704). Proportions of hospitalization for stroke subtypes were compared between the lupus group and the general population group. Age- and sex-adjusted odds ratios for stroke were calculated with logistic regression models.

RESULTS

In the lupus group, there were 313 hospitalizations for stroke of which 206 hospitalizations had stroke as the primary diagnosis. Age- and sex-adjusted stroke risk was higher among the lupus group (odds ratio 1.5, 95% confidence interval 1.3-1.8). Patients with lupus had higher risk for all stroke subtypes except in subarachnoid hemorrhage in which a trend toward a lower risk was observed (odds ratio 0.57, 95% confidence interval 0.34-0.96). Although 12.3% (n=38) of stroke admissions in the lupus group resulted in in-hospital death, this case fatality rate was not statistically different from that for stroke in the general population group.

CONCLUSIONS

Stroke is an important poor outcome in young patients with lupus. Compared with the general population, patients with lupus are more likely to be hospitalized for the risk of ischemic stroke and intracerebral hemorrhage. The risk of subarachnoid hemorrhage, however, seems to be lower in patients with lupus.

Authors+Show Affiliations

Department of Medicine, University of Pittsburgh, Pittsburgh, Pa, USA. eswar_krishnan@hotmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16378793

Citation

Krishnan, Eswar. "Stroke Subtypes Among Young Patients With Systemic Lupus Erythematosus." The American Journal of Medicine, vol. 118, no. 12, 2005, p. 1415.
Krishnan E. Stroke subtypes among young patients with systemic lupus erythematosus. Am J Med. 2005;118(12):1415.
Krishnan, E. (2005). Stroke subtypes among young patients with systemic lupus erythematosus. The American Journal of Medicine, 118(12), p. 1415.
Krishnan E. Stroke Subtypes Among Young Patients With Systemic Lupus Erythematosus. Am J Med. 2005;118(12):1415. PubMed PMID: 16378793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stroke subtypes among young patients with systemic lupus erythematosus. A1 - Krishnan,Eswar, PY - 2005/03/04/received PY - 2005/05/02/revised PY - 2005/05/02/accepted PY - 2005/12/28/pubmed PY - 2006/2/25/medline PY - 2005/12/28/entrez SP - 1415 EP - 1415 JF - The American journal of medicine JO - Am. J. Med. VL - 118 IS - 12 N2 - PURPOSE: Systemic lupus erythematosus (lupus) is a systemic inflammatory disease associated with premature atherosclerosis, vasculitis, coagulopathy, and excessive incidence of stroke, especially among young patients. Little is known about subtypes of stroke in lupus. METHODS: A 20% sample of all the hospitalizations in the United States in the years 2001 and 2002 (N approximately 15 million) were analyzed to identify hospitalizations of young patients (age < or =50 years) with systemic lupus erythematosus (n=25704). Proportions of hospitalization for stroke subtypes were compared between the lupus group and the general population group. Age- and sex-adjusted odds ratios for stroke were calculated with logistic regression models. RESULTS: In the lupus group, there were 313 hospitalizations for stroke of which 206 hospitalizations had stroke as the primary diagnosis. Age- and sex-adjusted stroke risk was higher among the lupus group (odds ratio 1.5, 95% confidence interval 1.3-1.8). Patients with lupus had higher risk for all stroke subtypes except in subarachnoid hemorrhage in which a trend toward a lower risk was observed (odds ratio 0.57, 95% confidence interval 0.34-0.96). Although 12.3% (n=38) of stroke admissions in the lupus group resulted in in-hospital death, this case fatality rate was not statistically different from that for stroke in the general population group. CONCLUSIONS: Stroke is an important poor outcome in young patients with lupus. Compared with the general population, patients with lupus are more likely to be hospitalized for the risk of ischemic stroke and intracerebral hemorrhage. The risk of subarachnoid hemorrhage, however, seems to be lower in patients with lupus. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/16378793/Stroke_subtypes_among_young_patients_with_systemic_lupus_erythematosus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(05)00497-3 DB - PRIME DP - Unbound Medicine ER -