Tags

Type your tag names separated by a space and hit enter

Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones.
Eur J Med Chem. 2006 Feb; 41(2):268-75.EJ

Abstract

A series of imidazo(4,5-b)pyridinylethoxypiperidones was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans-6, Candida albicans, Aspergillus niger, Candida albicans-51 and Aspergillus flavus. Structure-activity relationship led to the conclusion that compound 39 exerted strong in vitro antibacterial activity against Bacillus subtilis and Staphylococcus aureus whereas compounds 38 and 39 displayed promising antifungal activity against Aspergillus flavus. The interesting antimicrobial profile of compound 39 led us to select this derivative for further development.

Authors+Show Affiliations

Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16380194

Citation

Aridoss, G, et al. "Synthesis and in Vitro Microbiological Evaluation of Imidazo(4,5-b)pyridinylethoxypiperidones." European Journal of Medicinal Chemistry, vol. 41, no. 2, 2006, pp. 268-75.
Aridoss G, Balasubramanian S, Parthiban P, et al. Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones. Eur J Med Chem. 2006;41(2):268-75.
Aridoss, G., Balasubramanian, S., Parthiban, P., & Kabilan, S. (2006). Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones. European Journal of Medicinal Chemistry, 41(2), 268-75.
Aridoss G, et al. Synthesis and in Vitro Microbiological Evaluation of Imidazo(4,5-b)pyridinylethoxypiperidones. Eur J Med Chem. 2006;41(2):268-75. PubMed PMID: 16380194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones. AU - Aridoss,G, AU - Balasubramanian,S, AU - Parthiban,P, AU - Kabilan,S, Y1 - 2005/12/27/ PY - 2005/07/26/received PY - 2005/10/24/revised PY - 2005/10/25/accepted PY - 2005/12/29/pubmed PY - 2006/7/19/medline PY - 2005/12/29/entrez SP - 268 EP - 75 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 41 IS - 2 N2 - A series of imidazo(4,5-b)pyridinylethoxypiperidones was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans-6, Candida albicans, Aspergillus niger, Candida albicans-51 and Aspergillus flavus. Structure-activity relationship led to the conclusion that compound 39 exerted strong in vitro antibacterial activity against Bacillus subtilis and Staphylococcus aureus whereas compounds 38 and 39 displayed promising antifungal activity against Aspergillus flavus. The interesting antimicrobial profile of compound 39 led us to select this derivative for further development. SN - 0223-5234 UR - https://www.unboundmedicine.com/medline/citation/16380194/Synthesis_and_in_vitro_microbiological_evaluation_of_imidazo_45_b_pyridinylethoxypiperidones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(05)00305-3 DB - PRIME DP - Unbound Medicine ER -