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Spectrophotometric methods for the determination of Ibuprofen in tablets.
Pak J Pharm Sci. 2005 Oct; 18(4):1-6.PJ

Abstract

Ibuprofen in film coated tablets of different strengths has been determined using different spectrophotometric methods. These are: (i) the compensation method, (ii) a two wavelengths method, (iii) second-order and (iv) fourth-order derivative methods, and (v) a curve fitting method based upon computing the quadratic coefficient of the orthogonal polynomials expansion of its benzenoid absorption characteristics. All results were compared with the HPLC method of the B.P. 2003 using paired comparison. Developed methods have been validated and applied to different tablet formulations. Mean differences from the B.P. method were found to be -0.10, -0.30, -0.10, -0.16, -0.34%, respectively. In view of the relatively low specific absorbance of ibuprofen in the ultraviolet region [A (1%, 1 cm) =18.5 at 264 nm] its accurate and precise determination in different tablet formulations is challenging due to the presence of interferences from excipients.

Authors+Show Affiliations

Wahbi AA
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt. abdel_azizwahbi@yahoo.com
Hassan E
No affiliation info available
Hamdy D
No affiliation info available
Khamis E
No affiliation info available
Barary M
No affiliation info available

MeSH

Anti-Inflammatory Agents, Non-SteroidalChromatography, High Pressure LiquidCopperIbuprofenIndicators and ReagentsReproducibility of ResultsSolventsSpectrophotometry, UltravioletTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16380350

Citation

Wahbi, Abdel Aziz, et al. "Spectrophotometric Methods for the Determination of Ibuprofen in Tablets." Pakistan Journal of Pharmaceutical Sciences, vol. 18, no. 4, 2005, pp. 1-6.
Wahbi AA, Hassan E, Hamdy D, et al. Spectrophotometric methods for the determination of Ibuprofen in tablets. Pak J Pharm Sci. 2005;18(4):1-6.
Wahbi, A. A., Hassan, E., Hamdy, D., Khamis, E., & Barary, M. (2005). Spectrophotometric methods for the determination of Ibuprofen in tablets. Pakistan Journal of Pharmaceutical Sciences, 18(4), 1-6.
Wahbi AA, et al. Spectrophotometric Methods for the Determination of Ibuprofen in Tablets. Pak J Pharm Sci. 2005;18(4):1-6. PubMed PMID: 16380350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectrophotometric methods for the determination of Ibuprofen in tablets. AU - Wahbi,Abdel Aziz, AU - Hassan,Ekram, AU - Hamdy,Dalia, AU - Khamis,Essam, AU - Barary,Magda, PY - 2005/12/29/pubmed PY - 2006/1/21/medline PY - 2005/12/29/entrez SP - 1 EP - 6 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 18 IS - 4 N2 - Ibuprofen in film coated tablets of different strengths has been determined using different spectrophotometric methods. These are: (i) the compensation method, (ii) a two wavelengths method, (iii) second-order and (iv) fourth-order derivative methods, and (v) a curve fitting method based upon computing the quadratic coefficient of the orthogonal polynomials expansion of its benzenoid absorption characteristics. All results were compared with the HPLC method of the B.P. 2003 using paired comparison. Developed methods have been validated and applied to different tablet formulations. Mean differences from the B.P. method were found to be -0.10, -0.30, -0.10, -0.16, -0.34%, respectively. In view of the relatively low specific absorbance of ibuprofen in the ultraviolet region [A (1%, 1 cm) =18.5 at 264 nm] its accurate and precise determination in different tablet formulations is challenging due to the presence of interferences from excipients. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/16380350/Spectrophotometric_methods_for_the_determination_of_Ibuprofen_in_tablets_ DB - PRIME DP - Unbound Medicine ER -