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Dietary intake of antioxidants and risk of age-related macular degeneration.
JAMA 2005; 294(24):3101-7JAMA

Abstract

CONTEXT

Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness in developed countries. Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD.

OBJECTIVE

To investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident AMD.

DESIGN

Dietary intake was assessed at baseline in the Rotterdam Study (1990-1993) using a semiquantitative food frequency questionnaire. Incident AMD until final follow-up in 2004 was determined by grading fundus color transparencies in a masked way according to the International Classification and Grading System.

SETTING

Population-based cohort of all inhabitants aged 55 years or older in a middle-class suburb of Rotterdam, the Netherlands.

PARTICIPANTS

Of 5836 persons at risk of AMD at baseline, 4765 had reliable dietary data and 4170 participated in the follow-up.

MAIN OUTCOME MEASURE

Incident AMD, defined as soft distinct drusen with pigment alterations, indistinct or reticular drusen, geographic atrophy, or choroidal neovascularization.

RESULTS

Incident AMD occurred in 560 participants after a mean follow-up of 8.0 years (range, 0.3-13.9 years). Dietary intake of both vitamin E and zinc was inversely associated with incident AMD. The hazard ratio (HR) per standard deviation increase of intake for vitamin E was 0.92 (95% confidence interval [CI], 0.84-1.00) and for zinc was 0.91 (95% CI, 0.83-0.98). An above-median intake of all 4 nutrients, beta carotene, vitamin C, vitamin E, and zinc, was associated with a 35% reduced risk (HR, 0.65; 95% CI, 0.46-0.92) of AMD. Exclusion of supplement users did not affect the results.

CONCLUSION

In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons.

Authors+Show Affiliations

Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands;No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16380590

Citation

van Leeuwen, Redmer, et al. "Dietary Intake of Antioxidants and Risk of Age-related Macular Degeneration." JAMA, vol. 294, no. 24, 2005, pp. 3101-7.
van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA. 2005;294(24):3101-7.
van Leeuwen, R., Boekhoorn, S., Vingerling, J. R., Witteman, J. C., Klaver, C. C., Hofman, A., & de Jong, P. T. (2005). Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA, 294(24), pp. 3101-7.
van Leeuwen R, et al. Dietary Intake of Antioxidants and Risk of Age-related Macular Degeneration. JAMA. 2005 Dec 28;294(24):3101-7. PubMed PMID: 16380590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of antioxidants and risk of age-related macular degeneration. AU - van Leeuwen,Redmer, AU - Boekhoorn,Sharmila, AU - Vingerling,Johannes R, AU - Witteman,Jacqueline C M, AU - Klaver,Caroline C W, AU - Hofman,Albert, AU - de Jong,Paulus T V M, PY - 2005/12/29/pubmed PY - 2005/12/31/medline PY - 2005/12/29/entrez SP - 3101 EP - 7 JF - JAMA JO - JAMA VL - 294 IS - 24 N2 - CONTEXT: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness in developed countries. Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD. OBJECTIVE: To investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident AMD. DESIGN: Dietary intake was assessed at baseline in the Rotterdam Study (1990-1993) using a semiquantitative food frequency questionnaire. Incident AMD until final follow-up in 2004 was determined by grading fundus color transparencies in a masked way according to the International Classification and Grading System. SETTING: Population-based cohort of all inhabitants aged 55 years or older in a middle-class suburb of Rotterdam, the Netherlands. PARTICIPANTS: Of 5836 persons at risk of AMD at baseline, 4765 had reliable dietary data and 4170 participated in the follow-up. MAIN OUTCOME MEASURE: Incident AMD, defined as soft distinct drusen with pigment alterations, indistinct or reticular drusen, geographic atrophy, or choroidal neovascularization. RESULTS: Incident AMD occurred in 560 participants after a mean follow-up of 8.0 years (range, 0.3-13.9 years). Dietary intake of both vitamin E and zinc was inversely associated with incident AMD. The hazard ratio (HR) per standard deviation increase of intake for vitamin E was 0.92 (95% confidence interval [CI], 0.84-1.00) and for zinc was 0.91 (95% CI, 0.83-0.98). An above-median intake of all 4 nutrients, beta carotene, vitamin C, vitamin E, and zinc, was associated with a 35% reduced risk (HR, 0.65; 95% CI, 0.46-0.92) of AMD. Exclusion of supplement users did not affect the results. CONCLUSION: In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/16380590/Dietary_intake_of_antioxidants_and_risk_of_age_related_macular_degeneration_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.294.24.3101 DB - PRIME DP - Unbound Medicine ER -