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Plasma beta carotene in Alzheimer's disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau.
Neuro Endocrinol Lett 2005; 26(6):696-8NE

Abstract

We studied the plasma beta carotene concentrations in 40 Alzheimer's disease patients and the association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), cerebrospinal fluid beta-amyloid 1-42 (Abeta42) and cerebrospinal fluid total Tau. We found that patients with plasma beta carotene levels below the 25th percentile had 55% reduced ratios of Abeta40/Tau and 51% reduced ratios of Abeta 40/Abeta 42 compared with patients in the highest quartile. Mean Tau concentrations in the lowest quartile of plasma beta-carotene levels were 74% higher compared with the highest quartile of plasma beta-carotene levels. Thus, we could demonstrate an statistically significant association between beta carotene levels in plasma and neurochemical markers in the cerebrospinal fluid of Alzheimer's disease patients.

Authors+Show Affiliations

Neurological Department, Median-Klinik Bad Suelze, Germany. stuerenburg@uke.uni-hamburg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16380679

Citation

Stuerenburg, Hans Joerg, et al. "Plasma Beta Carotene in Alzheimer's Disease. Association With Cerebrospinal Fluid Beta-amyloid 1-40, (Abeta40), Beta-amyloid 1-42 (Abeta42) and Total Tau." Neuro Endocrinology Letters, vol. 26, no. 6, 2005, pp. 696-8.
Stuerenburg HJ, Ganzer S, Müller-Thomsen T. Plasma beta carotene in Alzheimer's disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau. Neuro Endocrinol Lett. 2005;26(6):696-8.
Stuerenburg, H. J., Ganzer, S., & Müller-Thomsen, T. (2005). Plasma beta carotene in Alzheimer's disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau. Neuro Endocrinology Letters, 26(6), pp. 696-8.
Stuerenburg HJ, Ganzer S, Müller-Thomsen T. Plasma Beta Carotene in Alzheimer's Disease. Association With Cerebrospinal Fluid Beta-amyloid 1-40, (Abeta40), Beta-amyloid 1-42 (Abeta42) and Total Tau. Neuro Endocrinol Lett. 2005;26(6):696-8. PubMed PMID: 16380679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma beta carotene in Alzheimer's disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau. AU - Stuerenburg,Hans Joerg, AU - Ganzer,Stefanie, AU - Müller-Thomsen,Tomas, PY - 2005/10/12/received PY - 2005/10/15/accepted PY - 2005/12/29/pubmed PY - 2006/6/3/medline PY - 2005/12/29/entrez SP - 696 EP - 8 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 26 IS - 6 N2 - We studied the plasma beta carotene concentrations in 40 Alzheimer's disease patients and the association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), cerebrospinal fluid beta-amyloid 1-42 (Abeta42) and cerebrospinal fluid total Tau. We found that patients with plasma beta carotene levels below the 25th percentile had 55% reduced ratios of Abeta40/Tau and 51% reduced ratios of Abeta 40/Abeta 42 compared with patients in the highest quartile. Mean Tau concentrations in the lowest quartile of plasma beta-carotene levels were 74% higher compared with the highest quartile of plasma beta-carotene levels. Thus, we could demonstrate an statistically significant association between beta carotene levels in plasma and neurochemical markers in the cerebrospinal fluid of Alzheimer's disease patients. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/16380679/Plasma_beta_carotene_in_Alzheimer's_disease__Association_with_cerebrospinal_fluid_beta_amyloid_1_40__Abeta40__beta_amyloid_1_42__Abeta42__and_total_Tau_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -