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Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients.
Neuro Endocrinol Lett. 2005 Dec; 26(6):775-9.NE

Abstract

OBJECTIVES

In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints.

METHODS

We recruited 24 patients (21 males and 3 females) having a triglyceride level above 300 mg/dl with no neurologic complaints and none of the other common causes of PN and they underwent an electroneurographic study. The distal motor or sensory latencies (DL), motor or sensory conduction velocities (CV), and motor or sensory amplitudes (AMP) were collected for the peroneal, posterior tibial, sural, median, and ulnar nerves and were considered abnormal if they fall above or below 2 standard deviations of reference values.

RESULTS

Our results show that 70.8% of the patients had a significant delay in the DL of the sural nerves and 66.7% had a significant delay in the DL of the median sensory fibers. 54.2% of the patients had a significant decrease in the motor CV in the posterior tibial nerves and 33.3% had a significant decrease in the sensory CV in the sural nerves. The means of the DL and CV were significantly different from reference values in most of the nerves. Amplitudes were the least if at all affected.

CONCLUSION

The pattern of the abnormalities affecting more the DL, the sensory nerves and the longer nerves of the lower extremities is suggestive of an early axonal polyneuropathy. We conclude that hypertriglyceridemia affects conduction parameters in peripheral nerves in a trend suggestive of early peripheral neuropathy.

Authors+Show Affiliations

Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16380709

Citation

Kassem, Hania S., et al. "Hypertriglyceridemia and Peripheral Neuropathy in Neurologically Asymptomatic Patients." Neuro Endocrinology Letters, vol. 26, no. 6, 2005, pp. 775-9.
Kassem HS, Azar ST, Zantout MS, et al. Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients. Neuro Endocrinol Lett. 2005;26(6):775-9.
Kassem, H. S., Azar, S. T., Zantout, M. S., & Sawaya, R. A. (2005). Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients. Neuro Endocrinology Letters, 26(6), 775-9.
Kassem HS, et al. Hypertriglyceridemia and Peripheral Neuropathy in Neurologically Asymptomatic Patients. Neuro Endocrinol Lett. 2005;26(6):775-9. PubMed PMID: 16380709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients. AU - Kassem,Hania S, AU - Azar,Sami T, AU - Zantout,Mira S, AU - Sawaya,Raja A, PY - 2005/09/29/received PY - 2005/08/24/accepted PY - 2005/12/29/pubmed PY - 2006/6/3/medline PY - 2005/12/29/entrez SP - 775 EP - 9 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 26 IS - 6 N2 - OBJECTIVES: In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints. METHODS: We recruited 24 patients (21 males and 3 females) having a triglyceride level above 300 mg/dl with no neurologic complaints and none of the other common causes of PN and they underwent an electroneurographic study. The distal motor or sensory latencies (DL), motor or sensory conduction velocities (CV), and motor or sensory amplitudes (AMP) were collected for the peroneal, posterior tibial, sural, median, and ulnar nerves and were considered abnormal if they fall above or below 2 standard deviations of reference values. RESULTS: Our results show that 70.8% of the patients had a significant delay in the DL of the sural nerves and 66.7% had a significant delay in the DL of the median sensory fibers. 54.2% of the patients had a significant decrease in the motor CV in the posterior tibial nerves and 33.3% had a significant decrease in the sensory CV in the sural nerves. The means of the DL and CV were significantly different from reference values in most of the nerves. Amplitudes were the least if at all affected. CONCLUSION: The pattern of the abnormalities affecting more the DL, the sensory nerves and the longer nerves of the lower extremities is suggestive of an early axonal polyneuropathy. We conclude that hypertriglyceridemia affects conduction parameters in peripheral nerves in a trend suggestive of early peripheral neuropathy. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/16380709/Hypertriglyceridemia_and_peripheral_neuropathy_in_neurologically_asymptomatic_patients_ L2 - https://medlineplus.gov/triglycerides.html DB - PRIME DP - Unbound Medicine ER -