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[The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract].
Zhongguo Zhong Yao Za Zhi. 2005 Sep; 30(18):1458-61.ZZ

Abstract

OBJECTIVE

To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract.

METHOD

The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program.

RESULT

The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively.

CONCLUSION

Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model.

Authors+Show Affiliations

Zhu W
Institute of Integrated Traditional and Western Medicine of Peking University First Hospital, Beijing 100034, China. zwwbx@163.com
Zhang L
No affiliation info available
Wang XM
No affiliation info available
Wang BX
No affiliation info available
Li XY
No affiliation info available

MeSH

Administration, OralAdultAnthraquinonesArea Under CurveChromatography, High Pressure LiquidDrugs, Chinese HerbalFemaleHumansMalePlants, MedicinalRheum

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16381472

Citation

Zhu, Wei, et al. "[The Pharmacokinetics of Rhein in 12 Healthy Volunteers After Oral Administration of Rhubarb Extract]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 30, no. 18, 2005, pp. 1458-61.
Zhu W, Zhang L, Wang XM, et al. [The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract]. Zhongguo Zhong Yao Za Zhi. 2005;30(18):1458-61.
Zhu, W., Zhang, L., Wang, X. M., Wang, B. X., & Li, X. Y. (2005). [The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 30(18), 1458-61.
Zhu W, et al. [The Pharmacokinetics of Rhein in 12 Healthy Volunteers After Oral Administration of Rhubarb Extract]. Zhongguo Zhong Yao Za Zhi. 2005;30(18):1458-61. PubMed PMID: 16381472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract]. AU - Zhu,Wei, AU - Zhang,Li, AU - Wang,Xue-Mei, AU - Wang,Bao-Xiu, AU - Li,Xiao-Ye, PY - 2005/12/31/pubmed PY - 2007/2/3/medline PY - 2005/12/31/entrez SP - 1458 EP - 61 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 30 IS - 18 N2 - OBJECTIVE: To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract. METHOD: The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program. RESULT: The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively. CONCLUSION: Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/16381472/[The_pharmacokinetics_of_rhein_in_12_healthy_volunteers_after_oral_administration_of_rhubarb_extract]_ DB - PRIME DP - Unbound Medicine ER -