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Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart.
Lipids. 2005 Oct; 40(10):995-8.L

Abstract

Flaxseed, echium, and canola oils contain alpha-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator. Despite canola oil having the lowest ALA content of the three n-3-containing vegetable oils, it was the most potent for elevating DHA (22:6n-3) levels in rat hearts and plasma. However, the relative potencies of the dietary oils for elevation of EPA (20:5n-3) in heart and plasma followed the same rank order as their ALA content, i.e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation.

Authors+Show Affiliations

Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16382570

Citation

Cleland, Leslie G., et al. "Paradoxical Effect of N-3-containing Vegetable Oils On Long-chain N-3 Fatty Acids in Rat Heart." Lipids, vol. 40, no. 10, 2005, pp. 995-8.
Cleland LG, Gibson RA, Pedler J, et al. Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. Lipids. 2005;40(10):995-8.
Cleland, L. G., Gibson, R. A., Pedler, J., & James, M. J. (2005). Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. Lipids, 40(10), 995-8.
Cleland LG, et al. Paradoxical Effect of N-3-containing Vegetable Oils On Long-chain N-3 Fatty Acids in Rat Heart. Lipids. 2005;40(10):995-8. PubMed PMID: 16382570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. AU - Cleland,Leslie G, AU - Gibson,Robert A, AU - Pedler,Janet, AU - James,Michael J, PY - 2005/12/31/pubmed PY - 2006/2/28/medline PY - 2005/12/31/entrez SP - 995 EP - 8 JF - Lipids JO - Lipids VL - 40 IS - 10 N2 - Flaxseed, echium, and canola oils contain alpha-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator. Despite canola oil having the lowest ALA content of the three n-3-containing vegetable oils, it was the most potent for elevating DHA (22:6n-3) levels in rat hearts and plasma. However, the relative potencies of the dietary oils for elevation of EPA (20:5n-3) in heart and plasma followed the same rank order as their ALA content, i.e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/16382570/Paradoxical_effect_of_n_3_containing_vegetable_oils_on_long_chain_n_3_fatty_acids_in_rat_heart_ L2 - https://link.springer.com/article/10.1007/s11745-005-1461-6 DB - PRIME DP - Unbound Medicine ER -