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The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth.
Clin Chem. 2006 Feb; 52(2):263-9.CC

Abstract

BACKGROUND

Two proteins carry vitamin B12 in plasma. Transcobalamin (TC) carries approximately 25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds approximately 80% of total cobalamin and is largely saturated with cobalamin.

METHODS

We investigated the distribution and the relationship between concentrations of cobalamin, total and holo forms of TC, and HC in blood samples from pregnant women just before delivery (n = 92) and in cord blood samples from their newborn babies. We also investigated the relationship between these proteins and concentrations of methylmalonic acid (MMA), the functional marker of vitamin B12 status.

RESULTS

Concentrations of total serum cobalamin, total HC, holoHC, and percentage of HC saturation were higher in cord blood than in the maternal blood (mean cobalamin, 268 vs 188 pmol/L; total HC, 648 vs 538 pmol/L; holoHC, 441 vs 237 pmol/L; HC saturation, 70% vs 47%). Moreover, total TC was low in cord blood, whereas both holoTC and TC saturation were higher in cord blood than in the maternal blood (mean total TC, 654 vs 1002 pmol/L; holoTC, 118 vs 53 pmol/L; TC saturation, 19.8% vs 5.4%). Higher maternal serum cobalamin was associated with higher cord blood holoTC and TC saturation (P <0.05). Gestational age was also a significant determinant of baby total TC, TC saturation, total HC, and holoHC.

CONCLUSION

The close correlation between the amounts of holoTC present in cord blood and in maternal serum supports the importance of maternal cobalamin status for ensuring a sufficient supply to the baby.

Authors+Show Affiliations

Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg/Saar, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16384893

Citation

Obeid, Rima, et al. "The Cobalamin-binding Proteins Transcobalamin and Haptocorrin in Maternal and Cord Blood Sera at Birth." Clinical Chemistry, vol. 52, no. 2, 2006, pp. 263-9.
Obeid R, Morkbak AL, Munz W, et al. The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth. Clin Chem. 2006;52(2):263-9.
Obeid, R., Morkbak, A. L., Munz, W., Nexo, E., & Herrmann, W. (2006). The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth. Clinical Chemistry, 52(2), 263-9.
Obeid R, et al. The Cobalamin-binding Proteins Transcobalamin and Haptocorrin in Maternal and Cord Blood Sera at Birth. Clin Chem. 2006;52(2):263-9. PubMed PMID: 16384893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth. AU - Obeid,Rima, AU - Morkbak,Anne L, AU - Munz,Winfried, AU - Nexo,Ebba, AU - Herrmann,Wolfgang, Y1 - 2005/12/29/ PY - 2005/12/31/pubmed PY - 2006/3/11/medline PY - 2005/12/31/entrez SP - 263 EP - 9 JF - Clinical chemistry JO - Clin Chem VL - 52 IS - 2 N2 - BACKGROUND: Two proteins carry vitamin B12 in plasma. Transcobalamin (TC) carries approximately 25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds approximately 80% of total cobalamin and is largely saturated with cobalamin. METHODS: We investigated the distribution and the relationship between concentrations of cobalamin, total and holo forms of TC, and HC in blood samples from pregnant women just before delivery (n = 92) and in cord blood samples from their newborn babies. We also investigated the relationship between these proteins and concentrations of methylmalonic acid (MMA), the functional marker of vitamin B12 status. RESULTS: Concentrations of total serum cobalamin, total HC, holoHC, and percentage of HC saturation were higher in cord blood than in the maternal blood (mean cobalamin, 268 vs 188 pmol/L; total HC, 648 vs 538 pmol/L; holoHC, 441 vs 237 pmol/L; HC saturation, 70% vs 47%). Moreover, total TC was low in cord blood, whereas both holoTC and TC saturation were higher in cord blood than in the maternal blood (mean total TC, 654 vs 1002 pmol/L; holoTC, 118 vs 53 pmol/L; TC saturation, 19.8% vs 5.4%). Higher maternal serum cobalamin was associated with higher cord blood holoTC and TC saturation (P <0.05). Gestational age was also a significant determinant of baby total TC, TC saturation, total HC, and holoHC. CONCLUSION: The close correlation between the amounts of holoTC present in cord blood and in maternal serum supports the importance of maternal cobalamin status for ensuring a sufficient supply to the baby. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/16384893/The_cobalamin_binding_proteins_transcobalamin_and_haptocorrin_in_maternal_and_cord_blood_sera_at_birth_ L2 - https://academic.oup.com/clinchem/article-lookup/doi/10.1373/clinchem.2005.057810 DB - PRIME DP - Unbound Medicine ER -