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JP-8 jet fuel exposure and divided attention test performance in 1991 Gulf War veterans.
Aviat Space Environ Med. 2005 Dec; 76(12):1136-44.AS

Abstract

INTRODUCTION

Previous research indicates that a large cohort of veterans from the 1991 Gulf War report polysymptomatic conditions. These syndromes often involve neurocognitive complaints, fatigue, and musculoskeletal symptoms, thus overlapping with civilian illnesses from low levels of environmental chemicals, chronic fatigue syndrome, and fibromyalgia.

METHODS

To test for time-dependent changes over repeated intermittent exposures, we evaluated objective performance on a computerized visual divided attention test in chronically unhealthy Gulf War veterans (n = 22 ill with low-level chemical intolerance (CI); n = 24 ill without CI), healthy Gulf War veterans (n = 23), and healthy Gulf War era veterans (n = 20). Testing was done before and after each of three weekly, double blind, low-level JP-8 jet fuel or clean air sham exposure laboratory sessions, including acoustic startle stimuli.

RESULTS

Unhealthy veterans receiving jet fuel had faster mean peripheral reaction times over sessions compared with unhealthy veterans receiving sham clean air exposures. Unhealthy Gulf veterans with CI exhibited faster post- vs. pre-session mean central reaction times compared with unhealthy Gulf veterans without CI. Findings were controlled for psychological distress variables.

DISCUSSION

These data on unhealthy Gulf veterans show an acceleration of divided attention task performance over the course of repeated low-level JP-8 exposures. The present faster reaction times are consistent with rat neurobehavioral studies on environmental toxicant cross-sensitization and nonlinear dose-response patterns with stimulant drugs, as well as some previous civilian studies using other exposure agents. Together with previous research findings, the data suggest involvement of central nervous system dopaminergic pathways in affected Gulf veterans.

Authors+Show Affiliations

Research Service, Southern Arizona VA Health Care System, USA. ibell@u.arizona.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16385767

Citation

Bell, Iris R., et al. "JP-8 Jet Fuel Exposure and Divided Attention Test Performance in 1991 Gulf War Veterans." Aviation, Space, and Environmental Medicine, vol. 76, no. 12, 2005, pp. 1136-44.
Bell IR, Brooks AJ, Baldwin CM, et al. JP-8 jet fuel exposure and divided attention test performance in 1991 Gulf War veterans. Aviat Space Environ Med. 2005;76(12):1136-44.
Bell, I. R., Brooks, A. J., Baldwin, C. M., Fernandez, M., Figueredo, A. J., & Witten, M. L. (2005). JP-8 jet fuel exposure and divided attention test performance in 1991 Gulf War veterans. Aviation, Space, and Environmental Medicine, 76(12), 1136-44.
Bell IR, et al. JP-8 Jet Fuel Exposure and Divided Attention Test Performance in 1991 Gulf War Veterans. Aviat Space Environ Med. 2005;76(12):1136-44. PubMed PMID: 16385767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - JP-8 jet fuel exposure and divided attention test performance in 1991 Gulf War veterans. AU - Bell,Iris R, AU - Brooks,Audrey J, AU - Baldwin,Carol M, AU - Fernandez,Mercedes, AU - Figueredo,Aurelio J, AU - Witten,Mark L, PY - 2006/1/3/pubmed PY - 2006/2/17/medline PY - 2006/1/3/entrez SP - 1136 EP - 44 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 76 IS - 12 N2 - INTRODUCTION: Previous research indicates that a large cohort of veterans from the 1991 Gulf War report polysymptomatic conditions. These syndromes often involve neurocognitive complaints, fatigue, and musculoskeletal symptoms, thus overlapping with civilian illnesses from low levels of environmental chemicals, chronic fatigue syndrome, and fibromyalgia. METHODS: To test for time-dependent changes over repeated intermittent exposures, we evaluated objective performance on a computerized visual divided attention test in chronically unhealthy Gulf War veterans (n = 22 ill with low-level chemical intolerance (CI); n = 24 ill without CI), healthy Gulf War veterans (n = 23), and healthy Gulf War era veterans (n = 20). Testing was done before and after each of three weekly, double blind, low-level JP-8 jet fuel or clean air sham exposure laboratory sessions, including acoustic startle stimuli. RESULTS: Unhealthy veterans receiving jet fuel had faster mean peripheral reaction times over sessions compared with unhealthy veterans receiving sham clean air exposures. Unhealthy Gulf veterans with CI exhibited faster post- vs. pre-session mean central reaction times compared with unhealthy Gulf veterans without CI. Findings were controlled for psychological distress variables. DISCUSSION: These data on unhealthy Gulf veterans show an acceleration of divided attention task performance over the course of repeated low-level JP-8 exposures. The present faster reaction times are consistent with rat neurobehavioral studies on environmental toxicant cross-sensitization and nonlinear dose-response patterns with stimulant drugs, as well as some previous civilian studies using other exposure agents. Together with previous research findings, the data suggest involvement of central nervous system dopaminergic pathways in affected Gulf veterans. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/16385767/JP_8_jet_fuel_exposure_and_divided_attention_test_performance_in_1991_Gulf_War_veterans_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0095-6562&volume=76&issue=12&spage=1136&aulast=Bell DB - PRIME DP - Unbound Medicine ER -