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[Diagnosis of vitamin B12 deficiency revised].
Ned Tijdschr Geneeskd. 2005 Dec 10; 149(50):2789-94.NT

Abstract

Vitamin B12 (cobalamin) deficiency is a common disorder with potential irreversible haematological and neurological consequences. Currently used diagnostic tests such as the evaluation of serum vitamin B12 and the Schilling test are insufficient, e.g. the positive predictive value of a low serum vitamin B12 level for actual vitamin B12 deficiency (i.e. tissue deficiency) is low. Insufficient availability of vitamin B12 will lead to the accumulation of methylmalonic acid and homocysteine in the body. Nearly all patients with vitamin B12 deficiency also have substantially increased levels of methylmalonic acid and homocysteine. New tests of serum methylmalonic acid and homocysteine are highly sensitive for vitamin B12 deficiency and may obviate the need for the somewhat cumbersome Schilling test.

Authors+Show Affiliations

Wiersinga WJ
Afd. Inwendige Geneeskunde, Academisch Medisch Centrum/Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam.
de Rooij SE
No affiliation info available
Huijmans JG
No affiliation info available
Fischer C
No affiliation info available
Hoekstra JB
No affiliation info available

MeSH

HomocysteineHumansMethylmalonic AcidPredictive Value of TestsSchilling TestSensitivity and SpecificityVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

16385831

Citation

Wiersinga, W J., et al. "[Diagnosis of Vitamin B12 Deficiency Revised]." Nederlands Tijdschrift Voor Geneeskunde, vol. 149, no. 50, 2005, pp. 2789-94.
Wiersinga WJ, de Rooij SE, Huijmans JG, et al. [Diagnosis of vitamin B12 deficiency revised]. Ned Tijdschr Geneeskd. 2005;149(50):2789-94.
Wiersinga, W. J., de Rooij, S. E., Huijmans, J. G., Fischer, C., & Hoekstra, J. B. (2005). [Diagnosis of vitamin B12 deficiency revised]. Nederlands Tijdschrift Voor Geneeskunde, 149(50), 2789-94.
Wiersinga WJ, et al. [Diagnosis of Vitamin B12 Deficiency Revised]. Ned Tijdschr Geneeskd. 2005 Dec 10;149(50):2789-94. PubMed PMID: 16385831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis of vitamin B12 deficiency revised]. AU - Wiersinga,W J, AU - de Rooij,S E J A, AU - Huijmans,J G M, AU - Fischer,C, AU - Hoekstra,J B L, PY - 2006/1/3/pubmed PY - 2006/2/17/medline PY - 2006/1/3/entrez SP - 2789 EP - 94 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 149 IS - 50 N2 - Vitamin B12 (cobalamin) deficiency is a common disorder with potential irreversible haematological and neurological consequences. Currently used diagnostic tests such as the evaluation of serum vitamin B12 and the Schilling test are insufficient, e.g. the positive predictive value of a low serum vitamin B12 level for actual vitamin B12 deficiency (i.e. tissue deficiency) is low. Insufficient availability of vitamin B12 will lead to the accumulation of methylmalonic acid and homocysteine in the body. Nearly all patients with vitamin B12 deficiency also have substantially increased levels of methylmalonic acid and homocysteine. New tests of serum methylmalonic acid and homocysteine are highly sensitive for vitamin B12 deficiency and may obviate the need for the somewhat cumbersome Schilling test. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/16385831/[Diagnosis_of_vitamin_B12_deficiency_revised]_ DB - PRIME DP - Unbound Medicine ER -