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Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion.
Eur J Pharmacol. 2006 Jan 13; 530(1-2):70-80.EJ

Abstract

Agonists of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) exert protective effects in several models of ischemia/reperfusion injury, but their role in stroke is less clear. The study investigates the effects of two PPAR-gamma agonists, rosiglitazone and pioglitazone, on oxidative stress and inflammatory response induced by ischemia/reperfusion in the rat hippocampus. Common carotid artery occlusion for 30 min followed by 1 h reperfusion resulted in a significant increase in the generation of reactive oxygen species, nitric oxide and the end products of lipid peroxidation as well as markedly reduced endogenous antioxidant glutathione levels and up-regulated superoxide dismutase activity. Western blot analysis showed that ischemia/reperfusion lead to an increase in cyclooxygenase-2 (COX-2) expression, as well activating p38 and p42/44 mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB). Pre-treatment with either rosiglitazone or pioglitazone significantly reduced oxidative stress, COX-2 protein expression and activation of MAPKs and NF-kappaB. Taken together, the results provide convincing evidence that PPAR-gamma agonists exert protective effects in a rat model of mild forebrain ischemia/reperfusion injury by inhibiting oxidative stress and excessive inflammatory response.

Authors+Show Affiliations

Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Torino, Italy. massimo.collino@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16386242

Citation

Collino, Massimo, et al. "Modulation of the Oxidative Stress and Inflammatory Response By PPAR-gamma Agonists in the Hippocampus of Rats Exposed to Cerebral Ischemia/reperfusion." European Journal of Pharmacology, vol. 530, no. 1-2, 2006, pp. 70-80.
Collino M, Aragno M, Mastrocola R, et al. Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol. 2006;530(1-2):70-80.
Collino, M., Aragno, M., Mastrocola, R., Gallicchio, M., Rosa, A. C., Dianzani, C., Danni, O., Thiemermann, C., & Fantozzi, R. (2006). Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. European Journal of Pharmacology, 530(1-2), 70-80.
Collino M, et al. Modulation of the Oxidative Stress and Inflammatory Response By PPAR-gamma Agonists in the Hippocampus of Rats Exposed to Cerebral Ischemia/reperfusion. Eur J Pharmacol. 2006 Jan 13;530(1-2):70-80. PubMed PMID: 16386242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. AU - Collino,Massimo, AU - Aragno,Manuela, AU - Mastrocola,Raffaella, AU - Gallicchio,Margherita, AU - Rosa,Arianna Carolina, AU - Dianzani,Chiara, AU - Danni,Oliviero, AU - Thiemermann,Christopher, AU - Fantozzi,Roberto, Y1 - 2005/12/28/ PY - 2005/08/04/received PY - 2005/11/17/revised PY - 2005/11/22/accepted PY - 2006/1/3/pubmed PY - 2006/3/22/medline PY - 2006/1/3/entrez SP - 70 EP - 80 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 530 IS - 1-2 N2 - Agonists of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) exert protective effects in several models of ischemia/reperfusion injury, but their role in stroke is less clear. The study investigates the effects of two PPAR-gamma agonists, rosiglitazone and pioglitazone, on oxidative stress and inflammatory response induced by ischemia/reperfusion in the rat hippocampus. Common carotid artery occlusion for 30 min followed by 1 h reperfusion resulted in a significant increase in the generation of reactive oxygen species, nitric oxide and the end products of lipid peroxidation as well as markedly reduced endogenous antioxidant glutathione levels and up-regulated superoxide dismutase activity. Western blot analysis showed that ischemia/reperfusion lead to an increase in cyclooxygenase-2 (COX-2) expression, as well activating p38 and p42/44 mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB). Pre-treatment with either rosiglitazone or pioglitazone significantly reduced oxidative stress, COX-2 protein expression and activation of MAPKs and NF-kappaB. Taken together, the results provide convincing evidence that PPAR-gamma agonists exert protective effects in a rat model of mild forebrain ischemia/reperfusion injury by inhibiting oxidative stress and excessive inflammatory response. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16386242/Modulation_of_the_oxidative_stress_and_inflammatory_response_by_PPAR_gamma_agonists_in_the_hippocampus_of_rats_exposed_to_cerebral_ischemia/reperfusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)01252-5 DB - PRIME DP - Unbound Medicine ER -