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Smoking, alcohol intake, estrogen use, and age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study.
Am J Ophthalmol 2006; 141(1):79-87AJ

Abstract

PURPOSE

To assess the association between smoking, alcohol intake, estrogen use, and both early age-related macular degeneration (AMD) (soft indistinct drusen, retinal pigment abnormalities) and advanced AMD (exudative AMD, geographic atrophy) in the Latino community.

DESIGN

Population-based, cross-sectional study.

METHODS

Complete ophthalmic examination included stereoscopic macular photographs graded with a modified Wisconsin Age-related Maculopathy Grading System. A history of smoking, alcohol intake, and exogenous estrogen use was obtained by interview. Logistic regression was performed, and odds ratios (OR) were calculated with each AMD lesion as a dependent variable.

RESULTS

There were 5875 participants (92.4%) with gradable photographs. Having ever smoked was associated with a higher risk of having advanced AMD (OR, 2.4). Heavy consumption of alcohol (>5 drinks per session) was significantly associated with a greater risk of having exudative AMD (OR, 5.8) and geographic atrophy (OR, 12.7) Beer drinking was associated with a higher risk of having advanced AMD (OR, 2.9), whereas wine drinking appeared to be protective for increased retinal pigment (OR, 0.7). Exogenous estrogen use also appeared to be protective from soft indistinct drusen (OR, 0.5) and increased retinal pigment (OR, 0.6), but power was limited in the assessment of its association with advanced AMD.

CONCLUSION

Smoking and heavy alcohol consumption, particularly beer, was associated with a greater risk of having advanced AMD; exogenous estrogen use appeared to have a weak protective effect in Latino participants. Similar modifiable risk factors have been identified previously in non-Hispanic white patients, which suggests that common pathogenic mechanisms may be associated with AMD in persons of different ethnicities.

Authors+Show Affiliations

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16386980

Citation

Fraser-Bell, Samantha, et al. "Smoking, Alcohol Intake, Estrogen Use, and Age-related Macular Degeneration in Latinos: the Los Angeles Latino Eye Study." American Journal of Ophthalmology, vol. 141, no. 1, 2006, pp. 79-87.
Fraser-Bell S, Wu J, Klein R, et al. Smoking, alcohol intake, estrogen use, and age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2006;141(1):79-87.
Fraser-Bell, S., Wu, J., Klein, R., Azen, S. P., & Varma, R. (2006). Smoking, alcohol intake, estrogen use, and age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study. American Journal of Ophthalmology, 141(1), pp. 79-87.
Fraser-Bell S, et al. Smoking, Alcohol Intake, Estrogen Use, and Age-related Macular Degeneration in Latinos: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2006;141(1):79-87. PubMed PMID: 16386980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking, alcohol intake, estrogen use, and age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study. AU - Fraser-Bell,Samantha, AU - Wu,Joanne, AU - Klein,Ronald, AU - Azen,Stanley P, AU - Varma,Rohit, PY - 2004/12/09/received PY - 2005/08/05/revised PY - 2005/08/05/accepted PY - 2006/1/3/pubmed PY - 2006/2/1/medline PY - 2006/1/3/entrez SP - 79 EP - 87 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 141 IS - 1 N2 - PURPOSE: To assess the association between smoking, alcohol intake, estrogen use, and both early age-related macular degeneration (AMD) (soft indistinct drusen, retinal pigment abnormalities) and advanced AMD (exudative AMD, geographic atrophy) in the Latino community. DESIGN: Population-based, cross-sectional study. METHODS: Complete ophthalmic examination included stereoscopic macular photographs graded with a modified Wisconsin Age-related Maculopathy Grading System. A history of smoking, alcohol intake, and exogenous estrogen use was obtained by interview. Logistic regression was performed, and odds ratios (OR) were calculated with each AMD lesion as a dependent variable. RESULTS: There were 5875 participants (92.4%) with gradable photographs. Having ever smoked was associated with a higher risk of having advanced AMD (OR, 2.4). Heavy consumption of alcohol (>5 drinks per session) was significantly associated with a greater risk of having exudative AMD (OR, 5.8) and geographic atrophy (OR, 12.7) Beer drinking was associated with a higher risk of having advanced AMD (OR, 2.9), whereas wine drinking appeared to be protective for increased retinal pigment (OR, 0.7). Exogenous estrogen use also appeared to be protective from soft indistinct drusen (OR, 0.5) and increased retinal pigment (OR, 0.6), but power was limited in the assessment of its association with advanced AMD. CONCLUSION: Smoking and heavy alcohol consumption, particularly beer, was associated with a greater risk of having advanced AMD; exogenous estrogen use appeared to have a weak protective effect in Latino participants. Similar modifiable risk factors have been identified previously in non-Hispanic white patients, which suggests that common pathogenic mechanisms may be associated with AMD in persons of different ethnicities. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16386980/Smoking_alcohol_intake_estrogen_use_and_age_related_macular_degeneration_in_Latinos:_the_Los_Angeles_Latino_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(05)00907-4 DB - PRIME DP - Unbound Medicine ER -