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Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases.

Abstract

Viral hepatic diseases, especially those induced by the hepatitis B virus, can progress into more serious pathological outcomes and eventually to hepatocellular carcinoma. A growing body of evidence indicates that many trace elements play important roles in a number of carcinogenic processes that proceed through various mechanisms. To examine the status of trace elements during the development of hepatic carcinoma, we determined the selenium, iron, copper, and zinc levels and copper-to-zinc ratios in the serum of patients at different stages of viral hepatic disease. We observed significant changes in the selenium, iron, copper, and zinc levels in the serum of patients having hepatocellular carcinoma, relative to those of healthy controls (p < 0.05). The mean serum copper level in patients with hepatocellular carcinoma was significantly higher than that of the control group. In contrast, the mean selenium, iron, and zinc levels in patients having hepatocellular carcinoma were significantly lower than those of the control group. In addition, the mean zinc level in the serum of patients with hepatic cirrhosis was significantly lower than that of the control group (p < 0.05). Moreover, we found markedly elevated Cu: Zn ratios (p < 0.05) in patients having hepatic cirrhosis or hepatocellular carcinoma. Our findings imply that the levels of some trace elements, such as selenium, iron, copper, and zinc, and Cu: Zn ratios, might serve as biomarkers for the increased severity of viral hepatic damage.

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  • Authors+Show Affiliations

    ,

    Department of Laboratory Medicine, and Basic Medical Science Education Center, Fooyin University Hospital, Pingtong, Taiwan.

    , ,

    Source

    Biological trace element research 109:1 2006 Jan pg 15-24

    MeSH

    Adolescent
    Adult
    Carcinoma, Hepatocellular
    Carrier State
    Copper
    Female
    Hepatitis B Surface Antigens
    Hepatitis B, Chronic
    Hepatitis C Antigens
    Humans
    Iron
    Liver Cirrhosis
    Liver Neoplasms
    Male
    Middle Aged
    Selenium
    Trace Elements
    Zinc

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16388099

    Citation

    Lin, Ching-Chiang, et al. "Selenium, Iron, Copper, and Zinc Levels and Copper-to-zinc Ratios in Serum of Patients at Different Stages of Viral Hepatic Diseases." Biological Trace Element Research, vol. 109, no. 1, 2006, pp. 15-24.
    Lin CC, Huang JF, Tsai LY, et al. Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biol Trace Elem Res. 2006;109(1):15-24.
    Lin, C. C., Huang, J. F., Tsai, L. Y., & Huang, Y. L. (2006). Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biological Trace Element Research, 109(1), pp. 15-24.
    Lin CC, et al. Selenium, Iron, Copper, and Zinc Levels and Copper-to-zinc Ratios in Serum of Patients at Different Stages of Viral Hepatic Diseases. Biol Trace Elem Res. 2006;109(1):15-24. PubMed PMID: 16388099.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. AU - Lin,Ching-Chiang, AU - Huang,Jee-Fu, AU - Tsai,Li-Yu, AU - Huang,Yeou-Lih, PY - 2005/04/22/received PY - 2005/05/10/accepted PY - 2006/1/3/pubmed PY - 2006/3/30/medline PY - 2006/1/3/entrez SP - 15 EP - 24 JF - Biological trace element research JO - Biol Trace Elem Res VL - 109 IS - 1 N2 - Viral hepatic diseases, especially those induced by the hepatitis B virus, can progress into more serious pathological outcomes and eventually to hepatocellular carcinoma. A growing body of evidence indicates that many trace elements play important roles in a number of carcinogenic processes that proceed through various mechanisms. To examine the status of trace elements during the development of hepatic carcinoma, we determined the selenium, iron, copper, and zinc levels and copper-to-zinc ratios in the serum of patients at different stages of viral hepatic disease. We observed significant changes in the selenium, iron, copper, and zinc levels in the serum of patients having hepatocellular carcinoma, relative to those of healthy controls (p < 0.05). The mean serum copper level in patients with hepatocellular carcinoma was significantly higher than that of the control group. In contrast, the mean selenium, iron, and zinc levels in patients having hepatocellular carcinoma were significantly lower than those of the control group. In addition, the mean zinc level in the serum of patients with hepatic cirrhosis was significantly lower than that of the control group (p < 0.05). Moreover, we found markedly elevated Cu: Zn ratios (p < 0.05) in patients having hepatic cirrhosis or hepatocellular carcinoma. Our findings imply that the levels of some trace elements, such as selenium, iron, copper, and zinc, and Cu: Zn ratios, might serve as biomarkers for the increased severity of viral hepatic damage. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/16388099/Selenium_iron_copper_and_zinc_levels_and_copper_to_zinc_ratios_in_serum_of_patients_at_different_stages_of_viral_hepatic_diseases_ L2 - https://dx.doi.org/10.1385/BTER:109:1:015 DB - PRIME DP - Unbound Medicine ER -