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Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression.
Acta Psychiatr Scand. 2006 Jan; 113(1):31-5.AP

Abstract

OBJECTIVE

Postpartum depression (PPD) affects 10-15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD.

METHOD

The efficacy of omega-3 fatty acids for PPD was assessed in an 8-week dose-ranging trial. Subjects were randomized to 0.5 g/day (n = 6), 1.4 g/day (n = 3), or 2.8 g/day (n = 7).

RESULTS

Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post-treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre- or post-test scores, or change in scores. The treatment was well tolerated.

CONCLUSION

This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD.

Authors+Show Affiliations

Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724-5002, USA. marlenef@email.arizona.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16390366

Citation

Freeman, M P., et al. "Randomized Dose-ranging Pilot Trial of Omega-3 Fatty Acids for Postpartum Depression." Acta Psychiatrica Scandinavica, vol. 113, no. 1, 2006, pp. 31-5.
Freeman MP, Hibbeln JR, Wisner KL, et al. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand. 2006;113(1):31-5.
Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Brumbach, B. H., Watchman, M., & Gelenberg, A. J. (2006). Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatrica Scandinavica, 113(1), 31-5.
Freeman MP, et al. Randomized Dose-ranging Pilot Trial of Omega-3 Fatty Acids for Postpartum Depression. Acta Psychiatr Scand. 2006;113(1):31-5. PubMed PMID: 16390366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. AU - Freeman,M P, AU - Hibbeln,J R, AU - Wisner,K L, AU - Brumbach,B H, AU - Watchman,M, AU - Gelenberg,A J, PY - 2006/1/5/pubmed PY - 2006/5/10/medline PY - 2006/1/5/entrez SP - 31 EP - 5 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 113 IS - 1 N2 - OBJECTIVE: Postpartum depression (PPD) affects 10-15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD. METHOD: The efficacy of omega-3 fatty acids for PPD was assessed in an 8-week dose-ranging trial. Subjects were randomized to 0.5 g/day (n = 6), 1.4 g/day (n = 3), or 2.8 g/day (n = 7). RESULTS: Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post-treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre- or post-test scores, or change in scores. The treatment was well tolerated. CONCLUSION: This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16390366/Randomized_dose_ranging_pilot_trial_of_omega_3_fatty_acids_for_postpartum_depression_ L2 - https://doi.org/10.1111/j.1600-0447.2005.00660.x DB - PRIME DP - Unbound Medicine ER -