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Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese.
Acta Psychiatr Scand. 2006 Jan; 113(1):48-53.AP

Abstract

OBJECTIVE

Major depression is an important comorbidity in Alzheimer's disease, which is definitely associated with the apolipoprotein E (apo E) polymorphism. The aim of this study was to explore the role of the different apo E polymorphisms in major depressive disorder (MDD) in a Taiwanese population.

METHOD

We examined apo E genotypes in 273 Taiwanese patients with MDD and 429 healthy community controls, and compared their polymorphism distribution.

RESULTS

The allelic frequency of apo epsilon2 was significantly lower in patients with MDD than in the controls, whereas no significant difference in apo epsilon4 allelic frequency between these two groups was found.

CONCLUSION

The apo epsilon4 allele was not associated with MDD in this study. However, the finding of a lower frequency of the apo epsilon2 allele in MDD could lead to the conclusion that the apo epsilon2 allele likely provides a protective effect against MDD in the Taiwanese population.

Authors+Show Affiliations

Military Kaohsiung General Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16390369

Citation

Fan, P-L, et al. "Protective Effect of the Apo Epsilon2 Allele in Major Depressive Disorder in Taiwanese." Acta Psychiatrica Scandinavica, vol. 113, no. 1, 2006, pp. 48-53.
Fan PL, Chen CD, Kao WT, et al. Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese. Acta Psychiatr Scand. 2006;113(1):48-53.
Fan, P. L., Chen, C. D., Kao, W. T., Shu, B. C., & Lung, F. W. (2006). Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese. Acta Psychiatrica Scandinavica, 113(1), 48-53.
Fan PL, et al. Protective Effect of the Apo Epsilon2 Allele in Major Depressive Disorder in Taiwanese. Acta Psychiatr Scand. 2006;113(1):48-53. PubMed PMID: 16390369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese. AU - Fan,P-L, AU - Chen,C-D, AU - Kao,W-T, AU - Shu,B-C, AU - Lung,F-W, PY - 2006/1/5/pubmed PY - 2006/5/10/medline PY - 2006/1/5/entrez SP - 48 EP - 53 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 113 IS - 1 N2 - OBJECTIVE: Major depression is an important comorbidity in Alzheimer's disease, which is definitely associated with the apolipoprotein E (apo E) polymorphism. The aim of this study was to explore the role of the different apo E polymorphisms in major depressive disorder (MDD) in a Taiwanese population. METHOD: We examined apo E genotypes in 273 Taiwanese patients with MDD and 429 healthy community controls, and compared their polymorphism distribution. RESULTS: The allelic frequency of apo epsilon2 was significantly lower in patients with MDD than in the controls, whereas no significant difference in apo epsilon4 allelic frequency between these two groups was found. CONCLUSION: The apo epsilon4 allele was not associated with MDD in this study. However, the finding of a lower frequency of the apo epsilon2 allele in MDD could lead to the conclusion that the apo epsilon2 allele likely provides a protective effect against MDD in the Taiwanese population. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16390369/Protective_effect_of_the_apo_epsilon2_allele_in_major_depressive_disorder_in_Taiwanese_ L2 - https://doi.org/10.1111/j.1600-0447.2005.00686.x DB - PRIME DP - Unbound Medicine ER -