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Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease.
Acta Psychiatr Scand. 2006 Jan; 113(1):59-63.AP

Abstract

OBJECTIVE

There have been inconclusive results to date on the association between the Apolipoprotein E (ApoE) genotype and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We investigated whether ApoE epsilon4 allele is associated with NPS in probable AD.

METHOD

Data for 197 subjects with probable AD were analysed. The Neuropsychiatric Inventory was used to evaluate the frequency and severity of NPS. Multiple logistic regression models were used to test the association between ApoE genotype and NPS in AD.

RESULTS

The ApoE epsilon3/3 genotype was present in 52.3%, epsilon3/4 in 44.1%, and epsilon4/4 in 3.6% of patients. ApoE epsilon4 carriers showed a higher frequency of apathy than non-carriers. After multiple adjustments, the ApoE epsilon4 allele was significantly associated with apathy.

CONCLUSION

Our results suggest a relationship between the ApoE epsilon4 allele and apathy in patients with AD.

Authors+Show Affiliations

Laboratory of Epidemiology and Psychology of Aging and Dementia, Section of Neurology and Psychiatry, DiNOOP, University of Palermo, Palermo, Italy. monastero@neuro.unipa.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16390371

Citation

Monastero, R, et al. "Association Between Apolipoprotein E Epsilon4 Allele and Apathy in Probable Alzheimer's Disease." Acta Psychiatrica Scandinavica, vol. 113, no. 1, 2006, pp. 59-63.
Monastero R, Mariani E, Camarda C, et al. Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease. Acta Psychiatr Scand. 2006;113(1):59-63.
Monastero, R., Mariani, E., Camarda, C., Ingegni, T., Averna, M. R., Senin, U., Camarda, R., & Mecocci, P. (2006). Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease. Acta Psychiatrica Scandinavica, 113(1), 59-63.
Monastero R, et al. Association Between Apolipoprotein E Epsilon4 Allele and Apathy in Probable Alzheimer's Disease. Acta Psychiatr Scand. 2006;113(1):59-63. PubMed PMID: 16390371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease. AU - Monastero,R, AU - Mariani,E, AU - Camarda,C, AU - Ingegni,T, AU - Averna,M R, AU - Senin,U, AU - Camarda,R, AU - Mecocci,P, PY - 2006/1/5/pubmed PY - 2006/5/10/medline PY - 2006/1/5/entrez SP - 59 EP - 63 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 113 IS - 1 N2 - OBJECTIVE: There have been inconclusive results to date on the association between the Apolipoprotein E (ApoE) genotype and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We investigated whether ApoE epsilon4 allele is associated with NPS in probable AD. METHOD: Data for 197 subjects with probable AD were analysed. The Neuropsychiatric Inventory was used to evaluate the frequency and severity of NPS. Multiple logistic regression models were used to test the association between ApoE genotype and NPS in AD. RESULTS: The ApoE epsilon3/3 genotype was present in 52.3%, epsilon3/4 in 44.1%, and epsilon4/4 in 3.6% of patients. ApoE epsilon4 carriers showed a higher frequency of apathy than non-carriers. After multiple adjustments, the ApoE epsilon4 allele was significantly associated with apathy. CONCLUSION: Our results suggest a relationship between the ApoE epsilon4 allele and apathy in patients with AD. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16390371/Association_between_apolipoprotein_E_epsilon4_allele_and_apathy_in_probable_Alzheimer's_disease_ L2 - https://doi.org/10.1111/j.1600-0447.2005.00597.x DB - PRIME DP - Unbound Medicine ER -