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Should mono- or poly-unsaturated fats replace saturated fat in the diet?
Eur J Clin Nutr. 1992 Jun; 46(6):429-36.EJ

Abstract

The effects of diets differing in saturated, monounsaturated and polyunsaturated fatty acid composition (SAFA, MUFA and PUFA, respectively) on plasma lipoproteins and factor VIIc were investigated in 28 middle-aged men and women with mild to moderate hyperlipidaemia. The subjects were stabilized on a diet with a total fat content fairly typical of New Zealand, containing approximately 40% energy as fat, before entering a randomized cross-over trial of diets high in PUFA (20% energy; SAFA and MUFA 10% each) or a high MUFA diet (20% energy; SAFA and PUFA 10% each). After 6-week periods on each diet the subjects returned to a high SAFA diet. Body weight and blood pressure remained unchanged during the study. Total and LDL cholesterol, HDL cholesterol and the HDL2 subfraction were significantly lower on both the MUFA and the PUFA diet than on SAFA. However, there were no statistically significant differences in lipoprotein concentrations on the MUFA and PUFA diet. Factor VIIc concentrations were similar on the three diets. The proportion of PUFA in a MUFA diet appears to be a major determinant of the relative lipoprotein response to such a diet. In order to avoid a reduction in HDL-C when replacing SAFA with MUFA it may be necessary to ensure that PUFA does not provide more than about 8% total energy. Thus careful planning is needed to identify the most appropriate foods to replace those rich in SAFA in diets designed to reduce the lipoprotein-mediated risk of coronary heart disease.

Authors+Show Affiliations

Foley M
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
Ball M
No affiliation info available
Chisholm A
No affiliation info available
Duncan A
No affiliation info available
Spears G
No affiliation info available
Mann J
No affiliation info available

MeSH

AgedAntigensCholesterol, HDLCholesterol, LDLDietary FatsFactor VIIFatty Acids, MonounsaturatedFatty Acids, UnsaturatedFemaleHumansHyperlipidemiasLipoproteinsMaleMiddle AgedTriglycerides

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1639051

Citation

Foley, M, et al. "Should Mono- or Poly-unsaturated Fats Replace Saturated Fat in the Diet?" European Journal of Clinical Nutrition, vol. 46, no. 6, 1992, pp. 429-36.
Foley M, Ball M, Chisholm A, et al. Should mono- or poly-unsaturated fats replace saturated fat in the diet? Eur J Clin Nutr. 1992;46(6):429-36.
Foley, M., Ball, M., Chisholm, A., Duncan, A., Spears, G., & Mann, J. (1992). Should mono- or poly-unsaturated fats replace saturated fat in the diet? European Journal of Clinical Nutrition, 46(6), 429-36.
Foley M, et al. Should Mono- or Poly-unsaturated Fats Replace Saturated Fat in the Diet. Eur J Clin Nutr. 1992;46(6):429-36. PubMed PMID: 1639051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Should mono- or poly-unsaturated fats replace saturated fat in the diet? AU - Foley,M, AU - Ball,M, AU - Chisholm,A, AU - Duncan,A, AU - Spears,G, AU - Mann,J, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 429 EP - 36 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 46 IS - 6 N2 - The effects of diets differing in saturated, monounsaturated and polyunsaturated fatty acid composition (SAFA, MUFA and PUFA, respectively) on plasma lipoproteins and factor VIIc were investigated in 28 middle-aged men and women with mild to moderate hyperlipidaemia. The subjects were stabilized on a diet with a total fat content fairly typical of New Zealand, containing approximately 40% energy as fat, before entering a randomized cross-over trial of diets high in PUFA (20% energy; SAFA and MUFA 10% each) or a high MUFA diet (20% energy; SAFA and PUFA 10% each). After 6-week periods on each diet the subjects returned to a high SAFA diet. Body weight and blood pressure remained unchanged during the study. Total and LDL cholesterol, HDL cholesterol and the HDL2 subfraction were significantly lower on both the MUFA and the PUFA diet than on SAFA. However, there were no statistically significant differences in lipoprotein concentrations on the MUFA and PUFA diet. Factor VIIc concentrations were similar on the three diets. The proportion of PUFA in a MUFA diet appears to be a major determinant of the relative lipoprotein response to such a diet. In order to avoid a reduction in HDL-C when replacing SAFA with MUFA it may be necessary to ensure that PUFA does not provide more than about 8% total energy. Thus careful planning is needed to identify the most appropriate foods to replace those rich in SAFA in diets designed to reduce the lipoprotein-mediated risk of coronary heart disease. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/1639051/Should_mono__or_poly_unsaturated_fats_replace_saturated_fat_in_the_diet DB - PRIME DP - Unbound Medicine ER -