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Estrogen replacement and exercise capacity in postmenopausal women: a randomized placebo-controlled study.
Gynecol Endocrinol. 2005 Dec; 21(6):324-9.GE

Abstract

OBJECTIVE

We tested the hypothesis that estrogen replacement (2 mg estradiol/day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women.

STUDY DESIGN

Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 +/- 2 years) and placebo control (n = 10, 58 +/- 2 years) groups. They performed a cardiopulmonary exercise test before and after the intervention.

RESULTS

Baseline measurements were similar between groups. Blood pressure and heart rate at rest and during exercise were unchanged by estrogen treatment, and estrogen did not alter pulmonary measurements at rest and during exercise. Oxygen consumption at anaerobic threshold, respiratory compensation point and peak exercise were lower after estrogen replacement, despite the unchanged workload and exercise time to exhaustion. In the placebo control group, no change in peak oxygen consumption, workload and time to exhaustion was found.

CONCLUSIONS

Estrogen does not change cardiopulmonary responses to submaximal and maximal exercise in postmenopausal women. In addition, estrogen fails to improve exercise capacity in postmenopausal women.

Authors+Show Affiliations

Aldrighi JM
Women's Climacteric Health Ambulatory, Public Health School, University of São Paulo, São Paulo, Brazil. jmaldri@usp.br
Calvoso-Júnior R
No affiliation info available
Alecrin IN
No affiliation info available
Trombetta IC
No affiliation info available
Negrão CE
No affiliation info available

MeSH

EstradiolEstrogen Replacement TherapyExercise TestExercise ToleranceFemaleGonadal Steroid HormonesHumansMiddle AgedPostmenopause

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16390780

Citation

Aldrighi, José M., et al. "Estrogen Replacement and Exercise Capacity in Postmenopausal Women: a Randomized Placebo-controlled Study." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 21, no. 6, 2005, pp. 324-9.
Aldrighi JM, Calvoso-Júnior R, Alecrin IN, et al. Estrogen replacement and exercise capacity in postmenopausal women: a randomized placebo-controlled study. Gynecol Endocrinol. 2005;21(6):324-9.
Aldrighi, J. M., Calvoso-Júnior, R., Alecrin, I. N., Trombetta, I. C., & Negrão, C. E. (2005). Estrogen replacement and exercise capacity in postmenopausal women: a randomized placebo-controlled study. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 21(6), 324-9.
Aldrighi JM, et al. Estrogen Replacement and Exercise Capacity in Postmenopausal Women: a Randomized Placebo-controlled Study. Gynecol Endocrinol. 2005;21(6):324-9. PubMed PMID: 16390780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen replacement and exercise capacity in postmenopausal women: a randomized placebo-controlled study. AU - Aldrighi,José M, AU - Calvoso-Júnior,Roberto, AU - Alecrin,Israel N, AU - Trombetta,Ivani C, AU - Negrão,Carlos E, PY - 2006/1/5/pubmed PY - 2006/5/10/medline PY - 2006/1/5/entrez SP - 324 EP - 9 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 21 IS - 6 N2 - OBJECTIVE: We tested the hypothesis that estrogen replacement (2 mg estradiol/day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women. STUDY DESIGN: Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 +/- 2 years) and placebo control (n = 10, 58 +/- 2 years) groups. They performed a cardiopulmonary exercise test before and after the intervention. RESULTS: Baseline measurements were similar between groups. Blood pressure and heart rate at rest and during exercise were unchanged by estrogen treatment, and estrogen did not alter pulmonary measurements at rest and during exercise. Oxygen consumption at anaerobic threshold, respiratory compensation point and peak exercise were lower after estrogen replacement, despite the unchanged workload and exercise time to exhaustion. In the placebo control group, no change in peak oxygen consumption, workload and time to exhaustion was found. CONCLUSIONS: Estrogen does not change cardiopulmonary responses to submaximal and maximal exercise in postmenopausal women. In addition, estrogen fails to improve exercise capacity in postmenopausal women. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16390780/Estrogen_replacement_and_exercise_capacity_in_postmenopausal_women:_a_randomized_placebo_controlled_study_ DB - PRIME DP - Unbound Medicine ER -