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Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets.
Ann Nutr Metab. 2006; 50(2):147-54.AN

Abstract

BACKGROUND/AIM

Effects of the dietary docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and fish oil on weekly changes in plasma glucose, total cholesterol, triacylglycerol, and phospholipid concentrations of male Crlj:CD-1 mice were investigated.

METHOD

Animals were fed five different experimental diets which contained 6.0% lard (lard diet), 6.0% fish oil (fish oil diet), 1.5% DHA-ethyl ester+4.5% lard (DHA diet), 0.4% EPA-ethyl ester+5.6% lard (EPA diet), and 1.5% DHA-ethyl ester+0.4% EPA ethyl ester+4.1% lard (DHA+EPA diet) for 17 weeks. Glucose and lipid concentrations in plasma collected at weeks 0, 1, 2, 4, 6, 8, 12, and 16 were measured.

RESULTS

Plasma phospholipid concentrations were significantly lower in mice fed the fish oil and DHA+EPA diets than in those fed the lard diet at week 2. Plasma total cholesterol and glucose concentrations were significantly lower in the fish oil diet group than in the lard diet group at weeks 6 and 8, respectively.

CONCLUSION

These results indicate that the decreases in plasma glucose concentrations in response to intakes of DHA and EPA in mice take place over a longer period of time than similar decreases in the plasma lipid concentrations.

Authors+Show Affiliations

Higuchi T
National Food Research Institute, Tsukuba, Japan. thiguchi@affrc.go.jp
Shirai N
No affiliation info available
Suzuki H
No affiliation info available

MeSH

AnimalsBlood GlucoseCholesterolDietary Fats, UnsaturatedDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsLipid MetabolismMaleMiceMice, Inbred ICRPhospholipidsRandom AllocationTime FactorsTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16391470

Citation

Higuchi, Tomoyuki, et al. "Reduction in Plasma Glucose After Lipid Changes in Mice Fed Fish Oil, Docosahexaenoic Acid, and Eicosapentaenoic Acid Diets." Annals of Nutrition & Metabolism, vol. 50, no. 2, 2006, pp. 147-54.
Higuchi T, Shirai N, Suzuki H. Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. Ann Nutr Metab. 2006;50(2):147-54.
Higuchi, T., Shirai, N., & Suzuki, H. (2006). Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. Annals of Nutrition & Metabolism, 50(2), 147-54.
Higuchi T, Shirai N, Suzuki H. Reduction in Plasma Glucose After Lipid Changes in Mice Fed Fish Oil, Docosahexaenoic Acid, and Eicosapentaenoic Acid Diets. Ann Nutr Metab. 2006;50(2):147-54. PubMed PMID: 16391470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. AU - Higuchi,Tomoyuki, AU - Shirai,Nobuya, AU - Suzuki,Hiramitsu, Y1 - 2006/01/02/ PY - 2005/04/22/received PY - 2005/08/18/accepted PY - 2006/1/5/pubmed PY - 2006/6/9/medline PY - 2006/1/5/entrez SP - 147 EP - 54 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 50 IS - 2 N2 - BACKGROUND/AIM: Effects of the dietary docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and fish oil on weekly changes in plasma glucose, total cholesterol, triacylglycerol, and phospholipid concentrations of male Crlj:CD-1 mice were investigated. METHOD: Animals were fed five different experimental diets which contained 6.0% lard (lard diet), 6.0% fish oil (fish oil diet), 1.5% DHA-ethyl ester+4.5% lard (DHA diet), 0.4% EPA-ethyl ester+5.6% lard (EPA diet), and 1.5% DHA-ethyl ester+0.4% EPA ethyl ester+4.1% lard (DHA+EPA diet) for 17 weeks. Glucose and lipid concentrations in plasma collected at weeks 0, 1, 2, 4, 6, 8, 12, and 16 were measured. RESULTS: Plasma phospholipid concentrations were significantly lower in mice fed the fish oil and DHA+EPA diets than in those fed the lard diet at week 2. Plasma total cholesterol and glucose concentrations were significantly lower in the fish oil diet group than in the lard diet group at weeks 6 and 8, respectively. CONCLUSION: These results indicate that the decreases in plasma glucose concentrations in response to intakes of DHA and EPA in mice take place over a longer period of time than similar decreases in the plasma lipid concentrations. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/16391470/Reduction_in_plasma_glucose_after_lipid_changes_in_mice_fed_fish_oil_docosahexaenoic_acid_and_eicosapentaenoic_acid_diets_ DB - PRIME DP - Unbound Medicine ER -