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Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects.

Abstract

OBJECTIVE

To investigate the effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma plasma total homocysteine (tHcy) concentrations in young Japanese male subjects.

DESIGN

In a double blind, randomized controlled trial.

INTERVENTION

Subjects were randomly assigned to one of four groups and received a placebo (control group), 800 microg/day folic acid (FA group), 8.4 mg/day riboflavin (R group), or both (FAR group) for 2 weeks.

SETTING

Tokyo, Japan.

SUBJECTS

In total, 32 healthy male volunteers aged 20-29 years.

RESULTS

At the end of the 2 week supplementation period, the tHcy concentration decreased significantly in the FA group. Serum folate concentrations had increased between 2.7 and 2.0-fold in the FA and FAR groups, respectively, but the mean within-group changes in serum folate and plasma tHcy concentrations did not differ between these two groups. At the end of the study, alanine amino transferase was decreased in the R and FAR groups, while alanine amino transferase was increased in the FA group.

CONCLUSION

Supplementation with folic acid, 800 microg/day, for 2 weeks, increased the serum and red blood cell folate concentrations and decreased the plasma tHcy concentrations in healthy young male subjects. Riboflavin supplementation may have blunted the effect of folic acid, which resulted in a diminished reduction of tHcy in our subjects.

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  • Authors+Show Affiliations

    ,

    Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, Tokyo, Japan. arakir@fc.jwu.ac.jp

    , , , , , ,

    Source

    MeSH

    Adult
    Alanine Transaminase
    Dietary Supplements
    Double-Blind Method
    Drug Interactions
    Erythrocytes
    Folic Acid
    Homocysteine
    Humans
    Hyperhomocysteinemia
    Male
    Riboflavin
    Vitamin B Complex

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16391577

    Citation

    Araki, R, et al. "Effects of Short-term Folic Acid And/or Riboflavin Supplementation On Serum Folate and Plasma Total Homocysteine Concentrations in Young Japanese Male Subjects." European Journal of Clinical Nutrition, vol. 60, no. 5, 2006, pp. 573-9.
    Araki R, Maruyama C, Igarashi S, et al. Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. Eur J Clin Nutr. 2006;60(5):573-9.
    Araki, R., Maruyama, C., Igarashi, S., Yoshida, M., Maruyama, T., Satoh, T., ... Umegaki, K. (2006). Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. European Journal of Clinical Nutrition, 60(5), pp. 573-9.
    Araki R, et al. Effects of Short-term Folic Acid And/or Riboflavin Supplementation On Serum Folate and Plasma Total Homocysteine Concentrations in Young Japanese Male Subjects. Eur J Clin Nutr. 2006;60(5):573-9. PubMed PMID: 16391577.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. AU - Araki,R, AU - Maruyama,C, AU - Igarashi,S, AU - Yoshida,M, AU - Maruyama,T, AU - Satoh,T, AU - Yoshida,M, AU - Umegaki,K, PY - 2006/1/5/pubmed PY - 2006/6/9/medline PY - 2006/1/5/entrez SP - 573 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 5 N2 - OBJECTIVE: To investigate the effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma plasma total homocysteine (tHcy) concentrations in young Japanese male subjects. DESIGN: In a double blind, randomized controlled trial. INTERVENTION: Subjects were randomly assigned to one of four groups and received a placebo (control group), 800 microg/day folic acid (FA group), 8.4 mg/day riboflavin (R group), or both (FAR group) for 2 weeks. SETTING: Tokyo, Japan. SUBJECTS: In total, 32 healthy male volunteers aged 20-29 years. RESULTS: At the end of the 2 week supplementation period, the tHcy concentration decreased significantly in the FA group. Serum folate concentrations had increased between 2.7 and 2.0-fold in the FA and FAR groups, respectively, but the mean within-group changes in serum folate and plasma tHcy concentrations did not differ between these two groups. At the end of the study, alanine amino transferase was decreased in the R and FAR groups, while alanine amino transferase was increased in the FA group. CONCLUSION: Supplementation with folic acid, 800 microg/day, for 2 weeks, increased the serum and red blood cell folate concentrations and decreased the plasma tHcy concentrations in healthy young male subjects. Riboflavin supplementation may have blunted the effect of folic acid, which resulted in a diminished reduction of tHcy in our subjects. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16391577/Effects_of_short_term_folic_acid_and/or_riboflavin_supplementation_on_serum_folate_and_plasma_total_homocysteine_concentrations_in_young_Japanese_male_subjects_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602351 DB - PRIME DP - Unbound Medicine ER -