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Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults.
Eur J Clin Nutr 2006; 60(6):727-33EJ

Abstract

OBJECTIVE

To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover.

DESIGN

Double-blinded randomised controlled intervention study.

SETTING

University of Ulster, Coleraine, Northern Ireland.

SUBJECTS

In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention.

INTERVENTIONS

Subjects were randomly assigned, to receive either 15 microg (600 IU) vitamin D(3) and 1,500 mg calcium/day (vitamin D group), or 1,500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

RESULTS

At baseline, vitamin D status was low in both the vitamin D group (47.9 (s.d. 16.0)) and the control group (55.5 (s.d. 18.6) nmol/l 25(OH)D). Post intervention vitamin D status was significantly higher in the vitamin D-treated group (86.5 (s.d. 24.5)) compared to the control group (48.3 (s.d. 16.8) nmol/l) (P<0.0001). There was no significant effect of supplementation on bone turnover markers or PTH concentrations.

CONCLUSIONS

This study suggests that young adults in Northern Ireland do not consume an adequate daily dietary intake of vitamin D to maintain plasma vitamin D concentrations in the wintertime. A daily supplement of 15 microg vitamin D(3) significantly increased vitamin D status in these individuals to levels of sufficiency. Achievement of an optimum vitamin D status among young adults may have future positive health implications.

Authors+Show Affiliations

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16391584

Citation

Barnes, M S., et al. "Effect of Vitamin D Supplementation On Vitamin D Status and Bone Turnover Markers in Young Adults." European Journal of Clinical Nutrition, vol. 60, no. 6, 2006, pp. 727-33.
Barnes MS, Robson PJ, Bonham MP, et al. Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults. Eur J Clin Nutr. 2006;60(6):727-33.
Barnes, M. S., Robson, P. J., Bonham, M. P., Strain, J. J., & Wallace, J. M. (2006). Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults. European Journal of Clinical Nutrition, 60(6), pp. 727-33.
Barnes MS, et al. Effect of Vitamin D Supplementation On Vitamin D Status and Bone Turnover Markers in Young Adults. Eur J Clin Nutr. 2006;60(6):727-33. PubMed PMID: 16391584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults. AU - Barnes,M S, AU - Robson,P J, AU - Bonham,M P, AU - Strain,J J, AU - Wallace,J M W, Y1 - 2006/01/04/ PY - 2006/1/5/pubmed PY - 2006/10/25/medline PY - 2006/1/5/entrez SP - 727 EP - 33 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 6 N2 - OBJECTIVE: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover. DESIGN: Double-blinded randomised controlled intervention study. SETTING: University of Ulster, Coleraine, Northern Ireland. SUBJECTS: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention. INTERVENTIONS: Subjects were randomly assigned, to receive either 15 microg (600 IU) vitamin D(3) and 1,500 mg calcium/day (vitamin D group), or 1,500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention. RESULTS: At baseline, vitamin D status was low in both the vitamin D group (47.9 (s.d. 16.0)) and the control group (55.5 (s.d. 18.6) nmol/l 25(OH)D). Post intervention vitamin D status was significantly higher in the vitamin D-treated group (86.5 (s.d. 24.5)) compared to the control group (48.3 (s.d. 16.8) nmol/l) (P<0.0001). There was no significant effect of supplementation on bone turnover markers or PTH concentrations. CONCLUSIONS: This study suggests that young adults in Northern Ireland do not consume an adequate daily dietary intake of vitamin D to maintain plasma vitamin D concentrations in the wintertime. A daily supplement of 15 microg vitamin D(3) significantly increased vitamin D status in these individuals to levels of sufficiency. Achievement of an optimum vitamin D status among young adults may have future positive health implications. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16391584/Effect_of_vitamin_D_supplementation_on_vitamin_D_status_and_bone_turnover_markers_in_young_adults_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602374 DB - PRIME DP - Unbound Medicine ER -