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Smoking and antihypertensive medication: interaction between blood pressure reduction and arterial stiffness.
Hypertens Res. 2005 Aug; 28(8):631-8.HR

Abstract

To investigate how cigarette smoking and antihypertensive drug therapy may interact to affect cardiovascular disease, in this prospective study we administered amlodipine to hypertensive smokers and non-smokers and compared blood pressure reduction and indices of arterial stiffness. We measured blood pressure (BP), heart rate (HR), brachial-ankle pulse wave velocity (baPWV), and the carotid augmentation index (AIx) by using a non-invasive automated device in 101 hypertensive patients at baseline and at 1, 3, and 6 months of amlodipine administration (5.0 mg). At baseline, the AIx was significantly lower in smokers (n=27) than in non-smokers (n=74) (27.3% +/- 13.3% vs. 33.3% +/- 11.4%). After amlodipine administration, in both the groups, the mean BP, baPWV, and AIx were significantly reduced; however, the HR did not show a statistically significant difference. The reduction in the baPWV (cm/s) at 1 and 3 months was less marked in smokers than in non-smokers (mean +/- SD: -186.6 +/- 36.5 vs. -283.6 +/- 24.5 at 1 month; -136.6 +/- 42.2 vs. -280.1 +/- 29.6 at 3 months, respectively, both p<0.05). At 6 months, these intergroup differences in the reductions of baPWV disappeared. The blunted reduction of baPWV, particularly at 3 months, was significantly associated with the extent of smoking (lifetime pack-years smoked). Changes observed in the AIx and mean BP were similar between groups throughout the study period. In the short term, cigarette smoking blunts the effect of amlodipine on the reduction of arterial stiffness, independently of the mean BP level.

Authors+Show Affiliations

Department of Internal Medicine, Miwa Municipal Hospital, Yamaguchi, Japan. y.matsui@ninus.ocn.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16392766

Citation

Matsui, Yoshio, et al. "Smoking and Antihypertensive Medication: Interaction Between Blood Pressure Reduction and Arterial Stiffness." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 28, no. 8, 2005, pp. 631-8.
Matsui Y, Kario K, Ishikawa J, et al. Smoking and antihypertensive medication: interaction between blood pressure reduction and arterial stiffness. Hypertens Res. 2005;28(8):631-8.
Matsui, Y., Kario, K., Ishikawa, J., Hoshide, S., Eguchi, K., & Shimada, K. (2005). Smoking and antihypertensive medication: interaction between blood pressure reduction and arterial stiffness. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 28(8), 631-8.
Matsui Y, et al. Smoking and Antihypertensive Medication: Interaction Between Blood Pressure Reduction and Arterial Stiffness. Hypertens Res. 2005;28(8):631-8. PubMed PMID: 16392766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and antihypertensive medication: interaction between blood pressure reduction and arterial stiffness. AU - Matsui,Yoshio, AU - Kario,Kazuomi, AU - Ishikawa,Joji, AU - Hoshide,Satoshi, AU - Eguchi,Kazuo, AU - Shimada,Kazuyuki, PY - 2006/1/6/pubmed PY - 2006/2/1/medline PY - 2006/1/6/entrez SP - 631 EP - 8 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens. Res. VL - 28 IS - 8 N2 - To investigate how cigarette smoking and antihypertensive drug therapy may interact to affect cardiovascular disease, in this prospective study we administered amlodipine to hypertensive smokers and non-smokers and compared blood pressure reduction and indices of arterial stiffness. We measured blood pressure (BP), heart rate (HR), brachial-ankle pulse wave velocity (baPWV), and the carotid augmentation index (AIx) by using a non-invasive automated device in 101 hypertensive patients at baseline and at 1, 3, and 6 months of amlodipine administration (5.0 mg). At baseline, the AIx was significantly lower in smokers (n=27) than in non-smokers (n=74) (27.3% +/- 13.3% vs. 33.3% +/- 11.4%). After amlodipine administration, in both the groups, the mean BP, baPWV, and AIx were significantly reduced; however, the HR did not show a statistically significant difference. The reduction in the baPWV (cm/s) at 1 and 3 months was less marked in smokers than in non-smokers (mean +/- SD: -186.6 +/- 36.5 vs. -283.6 +/- 24.5 at 1 month; -136.6 +/- 42.2 vs. -280.1 +/- 29.6 at 3 months, respectively, both p<0.05). At 6 months, these intergroup differences in the reductions of baPWV disappeared. The blunted reduction of baPWV, particularly at 3 months, was significantly associated with the extent of smoking (lifetime pack-years smoked). Changes observed in the AIx and mean BP were similar between groups throughout the study period. In the short term, cigarette smoking blunts the effect of amlodipine on the reduction of arterial stiffness, independently of the mean BP level. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/16392766/Smoking_and_antihypertensive_medication:_interaction_between_blood_pressure_reduction_and_arterial_stiffness_ L2 - http://dx.doi.org/10.1291/hypres.28.631 DB - PRIME DP - Unbound Medicine ER -