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Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis alone.
Clin Exp Allergy. 2006 Jan; 36(1):26-31.CE

Abstract

BACKGROUND

We have previously proposed that, compared with rhinitis alone, the constellation of upper and lower airway allergic disease is a manifestation of a more severe form of a syndrome affecting the entire airway. If this is correct, not only the lower, but also the upper airways of patients with asthma and rhinitis should demonstrate more abnormalities compared with patients with rhinitis alone, including higher sensitivity to irritant factors. Objective To test the hypothesis that, a previously well-studied natural nasal stimulus, cold, dry air (CDA), produces a stronger response in subjects with allergic rhinitis (AR) and asthma compared with subjects with AR alone.

METHODS

We performed nasal provocation with CDA on 24 individuals with asthma and rhinitis and 17 with rhinitis alone. Prior to and after the challenge, nasal symptoms were recorded using visual analogue scales and nasal lavages were performed to determine histamine and lysozyme levels.

RESULTS

The two groups reacted differently to CDA: after the challenge, patients with rhinitis and asthma reported significantly higher scores for nasal congestion, rhinorrhea and lacrimation. Also in this group, significant increases in histamine and in lysozyme levels in nasal lavage fluids were induced by CDA. In subjects with rhinitis alone, CDA failed to increase histamine or lysozyme levels above baseline. The CDA-induced change from baseline in histamine was significantly higher in the patients with rhinitis and asthma, compared with the rhinitis-only group.

CONCLUSION

Patients with AR and asthma have stronger nasal responsiveness to CDA compared with patients with rhinitis alone. This observation is consistent with the notion that compared with rhinitis alone, the presence of asthma and rhinitis signifies a higher degree of functional abnormality of the entire airway.

Authors+Show Affiliations

Department of Pediatrics, Children's Hospital of New York-Presbyterian, Columbia University, NewYork, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16393262

Citation

Hanes, L S., et al. "Stronger Nasal Responsiveness to Cold Air in Individuals With Rhinitis and Asthma, Compared With Rhinitis Alone." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 36, no. 1, 2006, pp. 26-31.
Hanes LS, Issa E, Proud D, et al. Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis alone. Clin Exp Allergy. 2006;36(1):26-31.
Hanes, L. S., Issa, E., Proud, D., & Togias, A. (2006). Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis alone. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 36(1), 26-31.
Hanes LS, et al. Stronger Nasal Responsiveness to Cold Air in Individuals With Rhinitis and Asthma, Compared With Rhinitis Alone. Clin Exp Allergy. 2006;36(1):26-31. PubMed PMID: 16393262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis alone. AU - Hanes,L S, AU - Issa,E, AU - Proud,D, AU - Togias,A, PY - 2006/1/6/pubmed PY - 2006/5/4/medline PY - 2006/1/6/entrez SP - 26 EP - 31 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 36 IS - 1 N2 - BACKGROUND: We have previously proposed that, compared with rhinitis alone, the constellation of upper and lower airway allergic disease is a manifestation of a more severe form of a syndrome affecting the entire airway. If this is correct, not only the lower, but also the upper airways of patients with asthma and rhinitis should demonstrate more abnormalities compared with patients with rhinitis alone, including higher sensitivity to irritant factors. Objective To test the hypothesis that, a previously well-studied natural nasal stimulus, cold, dry air (CDA), produces a stronger response in subjects with allergic rhinitis (AR) and asthma compared with subjects with AR alone. METHODS: We performed nasal provocation with CDA on 24 individuals with asthma and rhinitis and 17 with rhinitis alone. Prior to and after the challenge, nasal symptoms were recorded using visual analogue scales and nasal lavages were performed to determine histamine and lysozyme levels. RESULTS: The two groups reacted differently to CDA: after the challenge, patients with rhinitis and asthma reported significantly higher scores for nasal congestion, rhinorrhea and lacrimation. Also in this group, significant increases in histamine and in lysozyme levels in nasal lavage fluids were induced by CDA. In subjects with rhinitis alone, CDA failed to increase histamine or lysozyme levels above baseline. The CDA-induced change from baseline in histamine was significantly higher in the patients with rhinitis and asthma, compared with the rhinitis-only group. CONCLUSION: Patients with AR and asthma have stronger nasal responsiveness to CDA compared with patients with rhinitis alone. This observation is consistent with the notion that compared with rhinitis alone, the presence of asthma and rhinitis signifies a higher degree of functional abnormality of the entire airway. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16393262/Stronger_nasal_responsiveness_to_cold_air_in_individuals_with_rhinitis_and_asthma_compared_with_rhinitis_alone_ L2 - https://doi.org/10.1111/j.1365-2222.2006.02364.x DB - PRIME DP - Unbound Medicine ER -