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Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome.
Aliment Pharmacol Ther. 2006 Jan 01; 23(1):191-6.AP

Abstract

AIM

To determine the effect of a laxative alone and in combination with tegaserod in alleviating pain and improving stool frequency in adolescents with constipation predominant irritable bowel syndrome.

PATIENTS

Forty-eight postpubertal adolescents of both sexes with constipation predominant irritable bowel syndrome, as defined by Rome II criteria, were randomly allocated to Group A (n = 27) for treatment with a laxative (polyethylene glycol 3350 oral solution) only or Group B (n = 21) for combination therapy with the laxative and tegaserod. Symptoms of abdominal pain (scale 0-10) and frequency of bowel movements were recorded daily in the pre-treatment phase and the post-treatment phase after a 7-day 'washout' period. Patients served as their own controls.

RESULTS

Treatment with the laxative alone (Group A) resulted in significant increase in frequency of bowel movements (P < 0.05), but not significant improvement in pain (P > 0.05). Treatment with the combination of the laxative and tegaserod (Group B) led to significant increase in the frequency of bowel movements and also significant reduction in pain (P < 0.05).

CONCLUSIONS

The laxative alone improved stooling but not pain in adolescents with constipation predominant irritable bowel syndrome. Addition of tegaserod resulted in alleviation of pain as well.

Authors+Show Affiliations

West Jefferson Medical Center, New Orleans, LA 70072, USA. vkhoshoo@sbcglobal.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16393297

Citation

Khoshoo, V, et al. "Effect of a Laxative With and Without Tegaserod in Adolescents With Constipation Predominant Irritable Bowel Syndrome." Alimentary Pharmacology & Therapeutics, vol. 23, no. 1, 2006, pp. 191-6.
Khoshoo V, Armstead C, Landry L. Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2006;23(1):191-6.
Khoshoo, V., Armstead, C., & Landry, L. (2006). Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 23(1), 191-6.
Khoshoo V, Armstead C, Landry L. Effect of a Laxative With and Without Tegaserod in Adolescents With Constipation Predominant Irritable Bowel Syndrome. Aliment Pharmacol Ther. 2006 Jan 1;23(1):191-6. PubMed PMID: 16393297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome. AU - Khoshoo,V, AU - Armstead,C, AU - Landry,L, PY - 2006/1/6/pubmed PY - 2006/5/4/medline PY - 2006/1/6/entrez SP - 191 EP - 6 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 23 IS - 1 N2 - AIM: To determine the effect of a laxative alone and in combination with tegaserod in alleviating pain and improving stool frequency in adolescents with constipation predominant irritable bowel syndrome. PATIENTS: Forty-eight postpubertal adolescents of both sexes with constipation predominant irritable bowel syndrome, as defined by Rome II criteria, were randomly allocated to Group A (n = 27) for treatment with a laxative (polyethylene glycol 3350 oral solution) only or Group B (n = 21) for combination therapy with the laxative and tegaserod. Symptoms of abdominal pain (scale 0-10) and frequency of bowel movements were recorded daily in the pre-treatment phase and the post-treatment phase after a 7-day 'washout' period. Patients served as their own controls. RESULTS: Treatment with the laxative alone (Group A) resulted in significant increase in frequency of bowel movements (P < 0.05), but not significant improvement in pain (P > 0.05). Treatment with the combination of the laxative and tegaserod (Group B) led to significant increase in the frequency of bowel movements and also significant reduction in pain (P < 0.05). CONCLUSIONS: The laxative alone improved stooling but not pain in adolescents with constipation predominant irritable bowel syndrome. Addition of tegaserod resulted in alleviation of pain as well. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16393297/Effect_of_a_laxative_with_and_without_tegaserod_in_adolescents_with_constipation_predominant_irritable_bowel_syndrome_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02705.x DB - PRIME DP - Unbound Medicine ER -