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Stability of irritable bowel syndrome using a Rome II-based classification.
Aliment Pharmacol Ther 2006; 23(1):197-205AP

Abstract

BACKGROUND

As there is no biological marker for irritable bowel syndrome, a diagnosis is made using symptom-based criteria.

AIM

To evaluate the stability of self-reported symptoms consistent with Rome II-based irritable bowel syndrome classification.

METHODS

Irritable bowel syndrome subjects identified in a 2001 population-based study by modified Rome II criteria were re-contacted 2 years later. Data were collected via a web-based questionnaire.

RESULTS

Of the 697 subjects, 30% remained in the same irritable bowel syndrome subtype in both surveys, 18.4% changed irritable bowel syndrome subtype and 52% no longer met the irritable bowel syndrome criteria at follow-up. Subjects continuing to meet the irritable bowel syndrome criteria were more likely to have been initially classified in the alternating irritable bowel syndrome subtype and had more psychological impairment and lower irritable bowel syndrome-related quality of life than subjects not fulfilling the irritable bowel syndrome criteria at follow-up. Lack of pain caused more subjects to fall out of the irritable bowel syndrome criteria than the absence of non-painful bowel symptoms. However, the majority of subjects that did not fulfill the pain component of the irritable bowel syndrome criteria continued to report abdominal pain of at least moderate severity.

CONCLUSION

In a US population-based follow-up study using modified Rome II criteria, we found irritable bowel syndrome is episodic in nature and current classification is limited in capturing fluctuation of disease over time.

Authors+Show Affiliations

Worldwide Epidemiology, Glaxo SmithKline, Research Triangle Park, NC 27709, USA. rachel.e.williams@gsk.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16393298

Citation

Williams, R E., et al. "Stability of Irritable Bowel Syndrome Using a Rome II-based Classification." Alimentary Pharmacology & Therapeutics, vol. 23, no. 1, 2006, pp. 197-205.
Williams RE, Black CL, Kim HY, et al. Stability of irritable bowel syndrome using a Rome II-based classification. Aliment Pharmacol Ther. 2006;23(1):197-205.
Williams, R. E., Black, C. L., Kim, H. Y., Andrews, E. B., Mangel, A. W., Buda, J. J., & Cook, S. F. (2006). Stability of irritable bowel syndrome using a Rome II-based classification. Alimentary Pharmacology & Therapeutics, 23(1), pp. 197-205.
Williams RE, et al. Stability of Irritable Bowel Syndrome Using a Rome II-based Classification. Aliment Pharmacol Ther. 2006 Jan 1;23(1):197-205. PubMed PMID: 16393298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of irritable bowel syndrome using a Rome II-based classification. AU - Williams,R E, AU - Black,C L, AU - Kim,H-Y, AU - Andrews,E B, AU - Mangel,A W, AU - Buda,J J, AU - Cook,S F, PY - 2006/1/6/pubmed PY - 2006/5/4/medline PY - 2006/1/6/entrez SP - 197 EP - 205 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 23 IS - 1 N2 - BACKGROUND: As there is no biological marker for irritable bowel syndrome, a diagnosis is made using symptom-based criteria. AIM: To evaluate the stability of self-reported symptoms consistent with Rome II-based irritable bowel syndrome classification. METHODS: Irritable bowel syndrome subjects identified in a 2001 population-based study by modified Rome II criteria were re-contacted 2 years later. Data were collected via a web-based questionnaire. RESULTS: Of the 697 subjects, 30% remained in the same irritable bowel syndrome subtype in both surveys, 18.4% changed irritable bowel syndrome subtype and 52% no longer met the irritable bowel syndrome criteria at follow-up. Subjects continuing to meet the irritable bowel syndrome criteria were more likely to have been initially classified in the alternating irritable bowel syndrome subtype and had more psychological impairment and lower irritable bowel syndrome-related quality of life than subjects not fulfilling the irritable bowel syndrome criteria at follow-up. Lack of pain caused more subjects to fall out of the irritable bowel syndrome criteria than the absence of non-painful bowel symptoms. However, the majority of subjects that did not fulfill the pain component of the irritable bowel syndrome criteria continued to report abdominal pain of at least moderate severity. CONCLUSION: In a US population-based follow-up study using modified Rome II criteria, we found irritable bowel syndrome is episodic in nature and current classification is limited in capturing fluctuation of disease over time. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16393298/Stability_of_irritable_bowel_syndrome_using_a_Rome_II_based_classification_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02723.x DB - PRIME DP - Unbound Medicine ER -