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The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups.
Aliment Pharmacol Ther 2006; 23(2):321-9AP

Abstract

BACKGROUND

Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown.

AIM

To determine the extent of overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups.

METHODS

A total of 121 patients with gastro-oesophageal reflux disease underwent an upper endoscopy and were classified as having Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-all (non-erosive reflux disease-positive and functional heartburn). Subsequently, patients underwent pH testing and overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups was determined.

RESULTS

Of those enrolled, 24 had Barrett's oesophagus, 30 erosive oesophagitis and 28 were non-erosive reflux disease-positive. Mean oesophageal acid exposure time was 224.8 +/- 35, 134.3 +/- 21.9 and 141.3 +/- 19.8 min for Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-positive respectively. Per cent overlap for total, upright and supine time between non-erosive reflux disease-positive and erosive oesophagitis was 47.4%, 64.7% and 81.8%, between Barrett's oesophagus and erosive oesophagitis was 47.8%, 40.7% and 24%, and between Barrett's oesophagus and non-erosive reflux disease-positive was 31.6%, 37.5% and 20.8% respectively.

CONCLUSIONS

Our study demonstrated a high oesophageal acid exposure overlap between patients with non-erosive reflux disease-positive and erosive oesophagitis, Barrett's oesophagus and erosive oesophagitis, as well as Barrett's oesophagus and non-erosive reflux disease-positive patients.

Authors+Show Affiliations

The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16393313

Citation

Shapiro, M, et al. "The Extent of Oesophageal Acid Exposure Overlap Among the Different Gastro-oesophageal Reflux Disease Groups." Alimentary Pharmacology & Therapeutics, vol. 23, no. 2, 2006, pp. 321-9.
Shapiro M, Green C, Faybush EM, et al. The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups. Aliment Pharmacol Ther. 2006;23(2):321-9.
Shapiro, M., Green, C., Faybush, E. M., Esquivel, R. F., & Fass, R. (2006). The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups. Alimentary Pharmacology & Therapeutics, 23(2), pp. 321-9.
Shapiro M, et al. The Extent of Oesophageal Acid Exposure Overlap Among the Different Gastro-oesophageal Reflux Disease Groups. Aliment Pharmacol Ther. 2006 Jan 15;23(2):321-9. PubMed PMID: 16393313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups. AU - Shapiro,M, AU - Green,C, AU - Faybush,E M, AU - Esquivel,R F, AU - Fass,R, PY - 2006/1/6/pubmed PY - 2006/5/4/medline PY - 2006/1/6/entrez SP - 321 EP - 9 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 23 IS - 2 N2 - BACKGROUND: Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown. AIM: To determine the extent of overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups. METHODS: A total of 121 patients with gastro-oesophageal reflux disease underwent an upper endoscopy and were classified as having Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-all (non-erosive reflux disease-positive and functional heartburn). Subsequently, patients underwent pH testing and overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups was determined. RESULTS: Of those enrolled, 24 had Barrett's oesophagus, 30 erosive oesophagitis and 28 were non-erosive reflux disease-positive. Mean oesophageal acid exposure time was 224.8 +/- 35, 134.3 +/- 21.9 and 141.3 +/- 19.8 min for Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-positive respectively. Per cent overlap for total, upright and supine time between non-erosive reflux disease-positive and erosive oesophagitis was 47.4%, 64.7% and 81.8%, between Barrett's oesophagus and erosive oesophagitis was 47.8%, 40.7% and 24%, and between Barrett's oesophagus and non-erosive reflux disease-positive was 31.6%, 37.5% and 20.8% respectively. CONCLUSIONS: Our study demonstrated a high oesophageal acid exposure overlap between patients with non-erosive reflux disease-positive and erosive oesophagitis, Barrett's oesophagus and erosive oesophagitis, as well as Barrett's oesophagus and non-erosive reflux disease-positive patients. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16393313/The_extent_of_oesophageal_acid_exposure_overlap_among_the_different_gastro_oesophageal_reflux_disease_groups_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02747.x DB - PRIME DP - Unbound Medicine ER -