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Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life.
Clin Exp Allergy. 2005 Dec; 35(12):1550-6.CE

Abstract

BACKGROUND

Prenatal maternal smoking has been associated with adverse respiratory effects in childhood such as lung deficits and wheezing, but results concerning asthma, hayfever, and atopic eczema are inconsistent.

OBJECTIVE

In the present study, we investigate the effects of maternal smoking in pregnancy on asthma, hayfever, atopic eczema, and wheezing in the offspring up to the age of 14-18.

METHODS

The study was based on a cohort of mothers enrolled during midwife visits around the 36th week of gestation in Odense and Aalborg, Denmark, 1984-1987. Singleton, live born children (n = 11,144) were followed-up in 2002 to obtain a childhood history of atopic diseases, by means of questionnaires to the parents. Multivariate logistic regression analyses for medical diagnoses of asthma, hayfever, atopic eczema, and symptoms of wheezing before the age of 3, were carried out on 7844 children.

RESULTS

After adjustment for confounders, late prenatal smoke exposure was associated with wheezing, with an odds ratio (OR) of 1.2, and a 95% confidence interval (CI) of 1.1-1.5. Furthermore, slightly reduced estimates for hayfever (OR 0.8, CI 0.7-1.0) and atopic eczema (OR 0.8, CI 0.7-0.9) were obtained for children exposed in late pregnancy compared with non-exposed.

CONCLUSION

Late gestational smoke exposure was associated with wheezing but not with asthma, while null or even protective estimates were indicated for hayfever and atopic eczema. However, lack of control options for hereditary factors may have affected the results.

Authors+Show Affiliations

Magnusson LL
Department of Biosciences, Karolinska Institutet at Novum, Huddinge, Sweden. linda.magnusson@biosci.ki.se
Olesen AB
No affiliation info available
Wennborg H
No affiliation info available
Olsen J
No affiliation info available

MeSH

AdolescentAsthmaChildChild, PreschoolDenmarkDermatitis, AtopicFemaleGestational AgeHumansHypersensitivityInfantInfant, NewbornLogistic ModelsMalePregnancyPrenatal Exposure Delayed EffectsRespiratory SoundsRhinitis, Allergic, SeasonalRisk AssessmentSurveys and QuestionnairesTobacco Smoke Pollution

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16393320

Citation

Magnusson, L L., et al. "Wheezing, Asthma, Hayfever, and Atopic Eczema in Childhood Following Exposure to Tobacco Smoke in Fetal Life." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 12, 2005, pp. 1550-6.
Magnusson LL, Olesen AB, Wennborg H, et al. Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life. Clin Exp Allergy. 2005;35(12):1550-6.
Magnusson, L. L., Olesen, A. B., Wennborg, H., & Olsen, J. (2005). Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(12), 1550-6.
Magnusson LL, et al. Wheezing, Asthma, Hayfever, and Atopic Eczema in Childhood Following Exposure to Tobacco Smoke in Fetal Life. Clin Exp Allergy. 2005;35(12):1550-6. PubMed PMID: 16393320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life. AU - Magnusson,L L, AU - Olesen,A B, AU - Wennborg,H, AU - Olsen,J, PY - 2006/1/6/pubmed PY - 2006/5/5/medline PY - 2006/1/6/entrez SP - 1550 EP - 6 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 35 IS - 12 N2 - BACKGROUND: Prenatal maternal smoking has been associated with adverse respiratory effects in childhood such as lung deficits and wheezing, but results concerning asthma, hayfever, and atopic eczema are inconsistent. OBJECTIVE: In the present study, we investigate the effects of maternal smoking in pregnancy on asthma, hayfever, atopic eczema, and wheezing in the offspring up to the age of 14-18. METHODS: The study was based on a cohort of mothers enrolled during midwife visits around the 36th week of gestation in Odense and Aalborg, Denmark, 1984-1987. Singleton, live born children (n = 11,144) were followed-up in 2002 to obtain a childhood history of atopic diseases, by means of questionnaires to the parents. Multivariate logistic regression analyses for medical diagnoses of asthma, hayfever, atopic eczema, and symptoms of wheezing before the age of 3, were carried out on 7844 children. RESULTS: After adjustment for confounders, late prenatal smoke exposure was associated with wheezing, with an odds ratio (OR) of 1.2, and a 95% confidence interval (CI) of 1.1-1.5. Furthermore, slightly reduced estimates for hayfever (OR 0.8, CI 0.7-1.0) and atopic eczema (OR 0.8, CI 0.7-0.9) were obtained for children exposed in late pregnancy compared with non-exposed. CONCLUSION: Late gestational smoke exposure was associated with wheezing but not with asthma, while null or even protective estimates were indicated for hayfever and atopic eczema. However, lack of control options for hereditary factors may have affected the results. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16393320/Wheezing_asthma_hayfever_and_atopic_eczema_in_childhood_following_exposure_to_tobacco_smoke_in_fetal_life_ DB - PRIME DP - Unbound Medicine ER -