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A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.
Curr Med Res Opin. 2006 Jan; 22(1):67-73.CM

Abstract

OBJECTIVE

To assess the effects of dorzolamide/timolol fixed combination (DTFC) and latanoprost 0.005% on the retrobulbar haemodynamics and intraocular pressure (IOP) of open-angle glaucoma patients.

METHODS

22 consecutive subjects with newly diagnosed, open-angle glaucoma were included in this prospective, examiner masked, randomized, crossover study. The patients were randomized into two different arms. Peak systolic velocity (PSV), end-diastolic velocity (EDV), Pourcelot's resistance index (RI) and intraocular pressure (IOP) were determined at baseline and after 1 month of medical treatment with DTFC or latanoprost 0.005% in both groups. A 4-week washout period, without medical treatment, between study arms was carried out. Primary efficacy variables were the PSV, EDV and RI in the ophthalmic artery (OA) and short posterior ciliary artery (SPCA) and intraocular pressure (IOP). Inter- and intra-group comparisons were performed with a one-way ANOVA test and two-tailed paired Student's t-test respectively.

RESULTS

Intraocular pressure (IOP) and colour Doppler imaging (CDI) measurements were similar at baseline. Compared to baseline and washout measurements, only the fixed combination dorzolamide/timolol significantly increased the EDV in the OA and in the SPCA, p = 0.00012 and p = 0.00012, respectively and decreased the resistance index in the ophthalmic and short posterior ciliary arteries, p = 0.00011 and p = 0.00031, respectively. There were no statistically significant differences in the IOP lowering effect of either treatment.

CONCLUSION

Over a treatment period of 1 month, only the fixed combination dorzolamide/timolol seems to have a vascular effect on retrobulbar vessels. Further research is necessary to confirm these results.

Authors+Show Affiliations

Instituto Gallego de Oftalmologia, Hospital de Conxo, 15782 Santiago de Compostela, La Coruña, Spain. tontxu_1999@yahoo.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16393432

Citation

Martínez, Antonio, and Manuel Sánchez. "A Comparison of the Effects of 0.005% Latanoprost and Fixed Combination Dorzolamide/timolol On Retrobulbar Haemodynamics in Previously Untreated Glaucoma Patients." Current Medical Research and Opinion, vol. 22, no. 1, 2006, pp. 67-73.
Martínez A, Sánchez M. A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Curr Med Res Opin. 2006;22(1):67-73.
Martínez, A., & Sánchez, M. (2006). A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Current Medical Research and Opinion, 22(1), 67-73.
Martínez A, Sánchez M. A Comparison of the Effects of 0.005% Latanoprost and Fixed Combination Dorzolamide/timolol On Retrobulbar Haemodynamics in Previously Untreated Glaucoma Patients. Curr Med Res Opin. 2006;22(1):67-73. PubMed PMID: 16393432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. AU - Martínez,Antonio, AU - Sánchez,Manuel, PY - 2006/1/6/pubmed PY - 2006/4/21/medline PY - 2006/1/6/entrez SP - 67 EP - 73 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 22 IS - 1 N2 - OBJECTIVE: To assess the effects of dorzolamide/timolol fixed combination (DTFC) and latanoprost 0.005% on the retrobulbar haemodynamics and intraocular pressure (IOP) of open-angle glaucoma patients. METHODS: 22 consecutive subjects with newly diagnosed, open-angle glaucoma were included in this prospective, examiner masked, randomized, crossover study. The patients were randomized into two different arms. Peak systolic velocity (PSV), end-diastolic velocity (EDV), Pourcelot's resistance index (RI) and intraocular pressure (IOP) were determined at baseline and after 1 month of medical treatment with DTFC or latanoprost 0.005% in both groups. A 4-week washout period, without medical treatment, between study arms was carried out. Primary efficacy variables were the PSV, EDV and RI in the ophthalmic artery (OA) and short posterior ciliary artery (SPCA) and intraocular pressure (IOP). Inter- and intra-group comparisons were performed with a one-way ANOVA test and two-tailed paired Student's t-test respectively. RESULTS: Intraocular pressure (IOP) and colour Doppler imaging (CDI) measurements were similar at baseline. Compared to baseline and washout measurements, only the fixed combination dorzolamide/timolol significantly increased the EDV in the OA and in the SPCA, p = 0.00012 and p = 0.00012, respectively and decreased the resistance index in the ophthalmic and short posterior ciliary arteries, p = 0.00011 and p = 0.00031, respectively. There were no statistically significant differences in the IOP lowering effect of either treatment. CONCLUSION: Over a treatment period of 1 month, only the fixed combination dorzolamide/timolol seems to have a vascular effect on retrobulbar vessels. Further research is necessary to confirm these results. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/16393432/A_comparison_of_the_effects_of_0_005_latanoprost_and_fixed_combination_dorzolamide/timolol_on_retrobulbar_haemodynamics_in_previously_untreated_glaucoma_patients_ L2 - https://www.tandfonline.com/doi/full/10.1185/030079906X80215 DB - PRIME DP - Unbound Medicine ER -