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Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease.
Am J Clin Pathol. 2006 Feb; 125(2):184-92.AJ

Abstract

Smoking may affect epithelial repair and differentiation differentially in smokers with and without chronic obstructive pulmonary disease (COPD). We hypothesized that epithelial repair is disturbed in patients with COPD owing to higher expression of epidermal growth factor (EGF)-like factors and/or receptors. We studied epithelial expression of EGF, transforming growth factor a, amphiregulin, heregulin (HRG), betacellulin (BTC), and their receptors, EGFR, HER-2, and HER-3, by immunohistochemical analysis in resected bronchial tissue from 20 subjects with (forced expiratory volume in 1 second [FEV(1)] <75% of predicted value) and 18 without (FEV(1) >85% predicted value) COPD. All subjects underwent surgery for lung cancer. The proportion of intact, damaged, goblet, or squamous metaplastic epithelium was similar in subjects with and without COPD. Regardless of smoking status, HRG expression was higher in intact epithelium of patients with COPD than in those without. Subgroup analysis showed higher EGFR expression in intact epithelium (1.4 times; P pound .04) and higher EGF, BTC, and HRG expression in damaged epithelium (1.4-1.8 times; P<or=.05) of ex-smokers with COPD compared with ex-smokers without COPD. These data support our hypothesis and suggest that current smoking obscures intrinsically higher expression in COPD.

Authors+Show Affiliations

Departmen of Pulmonology, Leiden University Medical Center, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16393673

Citation

de Boer, Willem I., et al. "Expression of Epidermal Growth Factors and Their Receptors in the Bronchial Epithelium of Subjects With Chronic Obstructive Pulmonary Disease." American Journal of Clinical Pathology, vol. 125, no. 2, 2006, pp. 184-92.
de Boer WI, Hau CM, van Schadewijk A, et al. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am J Clin Pathol. 2006;125(2):184-92.
de Boer, W. I., Hau, C. M., van Schadewijk, A., Stolk, J., van Krieken, J. H., & Hiemstra, P. S. (2006). Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. American Journal of Clinical Pathology, 125(2), 184-92.
de Boer WI, et al. Expression of Epidermal Growth Factors and Their Receptors in the Bronchial Epithelium of Subjects With Chronic Obstructive Pulmonary Disease. Am J Clin Pathol. 2006;125(2):184-92. PubMed PMID: 16393673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. AU - de Boer,Willem I, AU - Hau,Chi M, AU - van Schadewijk,Annemarie, AU - Stolk,Jan, AU - van Krieken,J Han J M, AU - Hiemstra,Pieter S, PY - 2006/1/6/pubmed PY - 2006/3/3/medline PY - 2006/1/6/entrez SP - 184 EP - 92 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 125 IS - 2 N2 - Smoking may affect epithelial repair and differentiation differentially in smokers with and without chronic obstructive pulmonary disease (COPD). We hypothesized that epithelial repair is disturbed in patients with COPD owing to higher expression of epidermal growth factor (EGF)-like factors and/or receptors. We studied epithelial expression of EGF, transforming growth factor a, amphiregulin, heregulin (HRG), betacellulin (BTC), and their receptors, EGFR, HER-2, and HER-3, by immunohistochemical analysis in resected bronchial tissue from 20 subjects with (forced expiratory volume in 1 second [FEV(1)] <75% of predicted value) and 18 without (FEV(1) >85% predicted value) COPD. All subjects underwent surgery for lung cancer. The proportion of intact, damaged, goblet, or squamous metaplastic epithelium was similar in subjects with and without COPD. Regardless of smoking status, HRG expression was higher in intact epithelium of patients with COPD than in those without. Subgroup analysis showed higher EGFR expression in intact epithelium (1.4 times; P pound .04) and higher EGF, BTC, and HRG expression in damaged epithelium (1.4-1.8 times; P<or=.05) of ex-smokers with COPD compared with ex-smokers without COPD. These data support our hypothesis and suggest that current smoking obscures intrinsically higher expression in COPD. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/16393673/Expression_of_epidermal_growth_factors_and_their_receptors_in_the_bronchial_epithelium_of_subjects_with_chronic_obstructive_pulmonary_disease_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/W1AX-KGT7-UA37-X257 DB - PRIME DP - Unbound Medicine ER -