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Progressive periodontal disease and risk of very preterm delivery.
Obstet Gynecol. 2006 Jan; 107(1):29-36.OG

Abstract

OBJECTIVE

The goal was to estimate whether maternal periodontal disease was predictive of preterm (less than 37 weeks) or very preterm (less than 32 weeks) births.

METHODS

A prospective study of obstetric outcomes, entitled Oral Conditions and Pregnancy (OCAP), was conducted with 1,020 pregnant women who received both an antepartum and postpartum periodontal examination. Predictive models were developed to estimate whether maternal exposure to either periodontal disease at enrollment (less than 26 weeks) and/or periodontal disease progression during pregnancy, as determined by comparing postpartum with antepartum status, were predictive of preterm or very preterm births, adjusting for risk factors including previous preterm delivery, race, smoking, social domain variables, and other infections.

RESULTS

Incidence of preterm birth was 11.2% among periodontally healthy women, compared with 28.6% in women with moderate-severe periodontal disease (adjusted risk ratio [RR] 1.6, 95% confidence interval [CI] 1.1-2.3). Antepartum moderate-severe periodontal disease was associated with an increased incidence of spontaneous preterm births (15.2% versus 24.9%, adjusted RR 2.0, 95% CI 1.2-3.2). Similarly, the unadjusted rate of very preterm delivery was 6.4% among women with periodontal disease progression, significantly higher than the 1.8% rate among women without disease progression (adjusted RR 2.4, 95% CI 1.1-5.2).

CONCLUSION

The OCAP study demonstrates that maternal periodontal disease increases relative risk for preterm or spontaneous preterm births. Furthermore, periodontal disease progression during pregnancy was a predictor of the more severe adverse pregnancy outcome of very preterm birth, independently of traditional obstetric, periodontal, and social domain risk factors.

LEVEL OF EVIDENCE

II-2.

Authors+Show Affiliations

Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599-7455, USA. steve_offenbacher@dentistry.unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16394036

Citation

Offenbacher, Steven, et al. "Progressive Periodontal Disease and Risk of Very Preterm Delivery." Obstetrics and Gynecology, vol. 107, no. 1, 2006, pp. 29-36.
Offenbacher S, Boggess KA, Murtha AP, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol. 2006;107(1):29-36.
Offenbacher, S., Boggess, K. A., Murtha, A. P., Jared, H. L., Lieff, S., McKaig, R. G., Mauriello, S. M., Moss, K. L., & Beck, J. D. (2006). Progressive periodontal disease and risk of very preterm delivery. Obstetrics and Gynecology, 107(1), 29-36.
Offenbacher S, et al. Progressive Periodontal Disease and Risk of Very Preterm Delivery. Obstet Gynecol. 2006;107(1):29-36. PubMed PMID: 16394036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive periodontal disease and risk of very preterm delivery. AU - Offenbacher,Steven, AU - Boggess,Kim A, AU - Murtha,Amy P, AU - Jared,Heather L, AU - Lieff,Susan, AU - McKaig,Rosemary G, AU - Mauriello,Sally M, AU - Moss,Kevin L, AU - Beck,James D, PY - 2006/1/6/pubmed PY - 2006/3/3/medline PY - 2006/1/6/entrez SP - 29 EP - 36 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 107 IS - 1 N2 - OBJECTIVE: The goal was to estimate whether maternal periodontal disease was predictive of preterm (less than 37 weeks) or very preterm (less than 32 weeks) births. METHODS: A prospective study of obstetric outcomes, entitled Oral Conditions and Pregnancy (OCAP), was conducted with 1,020 pregnant women who received both an antepartum and postpartum periodontal examination. Predictive models were developed to estimate whether maternal exposure to either periodontal disease at enrollment (less than 26 weeks) and/or periodontal disease progression during pregnancy, as determined by comparing postpartum with antepartum status, were predictive of preterm or very preterm births, adjusting for risk factors including previous preterm delivery, race, smoking, social domain variables, and other infections. RESULTS: Incidence of preterm birth was 11.2% among periodontally healthy women, compared with 28.6% in women with moderate-severe periodontal disease (adjusted risk ratio [RR] 1.6, 95% confidence interval [CI] 1.1-2.3). Antepartum moderate-severe periodontal disease was associated with an increased incidence of spontaneous preterm births (15.2% versus 24.9%, adjusted RR 2.0, 95% CI 1.2-3.2). Similarly, the unadjusted rate of very preterm delivery was 6.4% among women with periodontal disease progression, significantly higher than the 1.8% rate among women without disease progression (adjusted RR 2.4, 95% CI 1.1-5.2). CONCLUSION: The OCAP study demonstrates that maternal periodontal disease increases relative risk for preterm or spontaneous preterm births. Furthermore, periodontal disease progression during pregnancy was a predictor of the more severe adverse pregnancy outcome of very preterm birth, independently of traditional obstetric, periodontal, and social domain risk factors. LEVEL OF EVIDENCE: II-2. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/16394036/Progressive_periodontal_disease_and_risk_of_very_preterm_delivery_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16394036.ui DB - PRIME DP - Unbound Medicine ER -