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Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis.
J Rheumatol 2006; 33(1):164-6JR

Abstract

OBJECTIVE

To estimate the occurrence of antithyroid antibodies (ATA) and hypothyroidism in children with juvenile idiopathic arthritis (JIA) compared to matched healthy controls.

METHODS

The occurrence of ATA, including antithyroglobulin (anti-TG) and antithyroid peroxidase (anti-TPO) antibodies, was evaluated by quantitative immunometric ELISA in children with JIA and in a healthy matched control group. Thyroid function was assessed in both groups.

RESULTS

The study group included 66 patients with JIA (50 girls, 16 boys) of mean age 11.7 +/- 4.4 years (range 2-23). The control group included 89 children (71 girls, 18 boys) of mean age 10.8 +/- 4.2 years (range 2-18). Mean age at onset of joint disease was 7.3 +/- 3.6 years (range 1-15). Anti-TG antibodies were found in 7 of 62 patients (11.3%) in the JIA group and 2 of 89 controls (2.2%) (p = 0.03); anti-TPO antibodies were found in 5 of 65 patients (7.9%) and one of 89 controls (1.1%) (p = 0.08). All patients with ATA had oligoarticular type JIA (p = 0.01). Mean thyroid stimulating hormone (TSH) levels were higher in the study group than in controls (2.6 +/- 2.3 vs 1.9 +/- 1.0 mIU/l; p = 0.01); levels were above normal range (0.4-4 mIU/l) in 8 study patients (12%) and 3 controls (3.4%) (p = 0.055). Overall, ATA were found in 9 of the 150 study participants, 4 (44%) of whom had TSH levels above 4 mIU/l (p = 0.001).

CONCLUSION

Children with JIA have a higher than normal incidence of ATA and subclinical hypothyroidism and should be routinely screened for these variables.

Authors+Show Affiliations

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16395764

Citation

Harel, Liora, et al. "Increased Prevalence of Antithyroid Antibodies and Subclinical Hypothyroidism in Children With Juvenile Idiopathic Arthritis." The Journal of Rheumatology, vol. 33, no. 1, 2006, pp. 164-6.
Harel L, Prais D, Uziel Y, et al. Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis. J Rheumatol. 2006;33(1):164-6.
Harel, L., Prais, D., Uziel, Y., Mukamel, M., Hashkes, P., Harel, G., ... Press, J. (2006). Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis. The Journal of Rheumatology, 33(1), pp. 164-6.
Harel L, et al. Increased Prevalence of Antithyroid Antibodies and Subclinical Hypothyroidism in Children With Juvenile Idiopathic Arthritis. J Rheumatol. 2006;33(1):164-6. PubMed PMID: 16395764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis. AU - Harel,Liora, AU - Prais,Dario, AU - Uziel,Yosef, AU - Mukamel,Masza, AU - Hashkes,Philip, AU - Harel,Gideon, AU - Amir,Jacob, AU - Monselise,Yehudit, AU - Press,Joseph, PY - 2006/1/6/pubmed PY - 2006/3/24/medline PY - 2006/1/6/entrez SP - 164 EP - 6 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 33 IS - 1 N2 - OBJECTIVE: To estimate the occurrence of antithyroid antibodies (ATA) and hypothyroidism in children with juvenile idiopathic arthritis (JIA) compared to matched healthy controls. METHODS: The occurrence of ATA, including antithyroglobulin (anti-TG) and antithyroid peroxidase (anti-TPO) antibodies, was evaluated by quantitative immunometric ELISA in children with JIA and in a healthy matched control group. Thyroid function was assessed in both groups. RESULTS: The study group included 66 patients with JIA (50 girls, 16 boys) of mean age 11.7 +/- 4.4 years (range 2-23). The control group included 89 children (71 girls, 18 boys) of mean age 10.8 +/- 4.2 years (range 2-18). Mean age at onset of joint disease was 7.3 +/- 3.6 years (range 1-15). Anti-TG antibodies were found in 7 of 62 patients (11.3%) in the JIA group and 2 of 89 controls (2.2%) (p = 0.03); anti-TPO antibodies were found in 5 of 65 patients (7.9%) and one of 89 controls (1.1%) (p = 0.08). All patients with ATA had oligoarticular type JIA (p = 0.01). Mean thyroid stimulating hormone (TSH) levels were higher in the study group than in controls (2.6 +/- 2.3 vs 1.9 +/- 1.0 mIU/l; p = 0.01); levels were above normal range (0.4-4 mIU/l) in 8 study patients (12%) and 3 controls (3.4%) (p = 0.055). Overall, ATA were found in 9 of the 150 study participants, 4 (44%) of whom had TSH levels above 4 mIU/l (p = 0.001). CONCLUSION: Children with JIA have a higher than normal incidence of ATA and subclinical hypothyroidism and should be routinely screened for these variables. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/16395764/Increased_prevalence_of_antithyroid_antibodies_and_subclinical_hypothyroidism_in_children_with_juvenile_idiopathic_arthritis_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=16395764 DB - PRIME DP - Unbound Medicine ER -